Moradi Anahita, Honarjoo Naser, Besalatpour Ali Asghar, Etemadifar Masoud
Department of Soil Science, Islamic Azad University, Isfahan (Khorasgan) Branch, Jei Street , Isfahan, 81551-39998, Iran.
inter 3 - Institute Fur Resource Management, Berlin, Germany.
Environ Monit Assess. 2023 Mar 16;195(4):471. doi: 10.1007/s10661-023-11017-y.
In recent decades, multiple sclerosis (MS) diseases have been significantly prevalent in some industrial areas of Iran, such as steel industrial areas in Isfahan province (central Iran). In this study, the environmental impacts of two steel mill factories in Isfahan province and their effects on the spread of MS in the region were investigated. To examine the extent of exposure, seasonal dust samples were collected from 15 sites around the two investigated factories. The annual dust deposition rate (DDR) was then determined and the concentrations of lead (Pb), cadmium (Cd), nickel (Ni), cobalt (Co), and manganese (Mn) in the dust samples were measured. Furthermore, the concentration of the mentioned elements was determined in the nail samples taken from 40 MS patients and 40 healthy people (control) living in the study region. The interpolated map extracted from the DDR values showed the highest dust deposition around the two studied steel factories, which decreases with increasing distance from them. The enrichment factor (EF) of heavy metals was the highest at the distance between the two steel factories, decreasing by moving away from them which indicate that these two steel factories are the source of investigated heavy metals in the region. The statistical analysis also revealed significant differences (P < 0.01) between the concentration of heavy metals measured in nail samples taken from MS patients and healthy people. The mean Pb concentration measured in the nail sample taken from MS patients was more than 18 times that of healthy people (93.45 and 5.02 mg/kg, respectively). These results revealed a buildup of heavy metals in the body of MS patients much more than usual, originating from the activities of two investigated steel companies in the region.
近几十年来，多发性硬化症（MS）在伊朗的一些工业区显著流行，比如伊斯法罕省（伊朗中部）的钢铁工业区。在本研究中，调查了伊斯法罕省两家钢铁厂的环境影响及其对该地区MS传播的影响。为了检测暴露程度，从两家被调查工厂周围的15个地点采集了季节性灰尘样本。然后测定了年灰尘沉积率（DDR），并测量了灰尘样本中铅（Pb）、镉（Cd）、镍（Ni）、钴（Co）和锰（Mn）的浓度。此外，还测定了从生活在研究区域的40名MS患者和40名健康人（对照组）采集的指甲样本中上述元素的浓度。从DDR值提取的插值地图显示，在两家研究的钢铁厂周围灰尘沉积最高，随着与它们距离的增加而降低。重金属的富集因子（EF）在两家钢铁厂之间的距离处最高，远离它们时降低，这表明这两家钢铁厂是该地区被调查重金属的来源。统计分析还显示，从MS患者和健康人采集的指甲样本中测量的重金属浓度之间存在显著差异（P < 0.01）。从MS患者采集的指甲样本中测量的平均Pb浓度是健康人的18倍多（分别为93.45和5.02毫克/千克）。这些结果表明，MS患者体内重金属的积累比平常多得多，这源于该地区两家被调查钢铁公司的活动。
