5 至 11 岁儿童中第三剂 BNT162b2 mRNA COVID-19 疫苗的免疫原性和安全性。
Immunogenicity and Safety of a Third COVID-19 BNT162b2 mRNA Vaccine Dose in 5- to 11-Year Olds.
机构信息
Children's Hospital Colorado and University of Colorado School of Medicine, Aurora, CO, USA.
Kaiser Permanente Vaccine Study Center, Kaiser Permanente Northern California, Oakland, CA, USA.
出版信息
J Pediatric Infect Dis Soc. 2023 Apr 28;12(4):234-238. doi: 10.1093/jpids/piad015.
Abstract
In this ongoing study, substantially increased ancestral SARS-CoV-2 neutralizing responses were observed 1 month after a third 10-µg BNT162b2 dose given to 5 to 11-year olds versus neutralizing responses post-dose 2. After dose 3, increased neutralizing responses against Omicron BA.1 and BA.4/BA.5 strains were also observed. The safety/tolerability profile was acceptable. (NCT04816643).
摘要
在这项正在进行的研究中，与第二剂后相比，5 至 11 岁儿童接种第三剂 10µg BNT162b2 后 1 个月，观察到针对 SARS-CoV-2 的祖先中和抗体反应显著增加。接种第三剂后，对奥密克戎 BA.1 和 BA.4/BA.5 株的中和抗体反应也有所增加。安全性/耐受性特征是可以接受的。（NCT04816643）。
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