Department of Gastroenterology, Beijing Friendship Hospital, National Clinical Research Center for Digestive Disease, Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, Capital Medical University, Beijing, 100050, P. R. China.
International Medical Center, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, P. R. China.
Adv Healthc Mater. 2023 Jul;12(19):e2300069. doi: 10.1002/adhm.202300069. Epub 2023 Mar 29.
Inflammatory bowel disease (IBD), a chronic and recurrent gastrointestinal inflammatory disorder with a variety of painful clinical manifestations and an increased risk of cancerization or death, has become an emerging challenge to global healthcare due to its rapidly increasing incidence. At present, there is no efficient cure against IBD because of the elusive etiology and pathogenesis of IBD. Therefore, the development of alternative therapeutic strategies with positive clinical efficacy and reduced side effects is urgently needed. In recent years, the great prosperity of nanomedicine promoted by a variety of advanced nanomaterials is redefining more attractive and promising therapeutic strategies for IBD owing to their advantages in the physiological stability, bioavailability, and targeting of inflammatory sites. In this review, firstly the basic characteristics of healthy and inflammatory intestinal microenvironments are presented. Then, different administration routes and targeting strategies of nanotherapeutics for IBD treatment are reviewed. Subsequently, a specific focus is placed on the introduction of nanotherapeutic treatments based on different IBD pathogenesis. Finally, some future challenges and perspectives of the currently developed nanomedicines for IBD treatment are provided. It is believed that the above topics will attract researchers from various fields including medicine, biological sciences, materials, chemistry and pharmaceutics.
炎症性肠病（IBD）是一种慢性复发性胃肠道炎症性疾病，具有多种疼痛的临床表现，且癌症化或死亡的风险增加，由于其发病率迅速增加，已成为全球医疗保健的新挑战。目前，由于 IBD 的病因和发病机制难以捉摸，因此还没有有效的治疗方法。因此，迫切需要开发具有积极临床疗效和减少副作用的替代治疗策略。近年来，多种先进纳米材料推动的纳米医学的蓬勃发展，由于其在炎症部位的生理稳定性、生物利用度和靶向性方面的优势，正在为 IBD 重新定义更具吸引力和前景的治疗策略。在这篇综述中，首先介绍了健康和炎症性肠道微环境的基本特征。然后，综述了用于 IBD 治疗的纳米药物的不同给药途径和靶向策略。随后，特别关注了基于不同 IBD 发病机制的纳米治疗方法的介绍。最后，提供了目前用于 IBD 治疗的纳米药物所面临的一些未来挑战和展望。相信上述主题将吸引来自医学、生物科学、材料、化学和药剂学等各个领域的研究人员。
