Faculty of Pharmacy, Nootan Pharmacy College, Sankalchand Patel University, Visnagar, 384315, Gujarat, India.
Department of Pharmaceutical Chemistry, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, 425405, MH, India.
Mol Cell Biochem. 2023 Dec;478(12):2763-2777. doi: 10.1007/s11010-023-04697-0. Epub 2023 Mar 16.
Allyl isothiocyanates (AITC) have gained recognition in recent years as effective chemotherapeutic and epigenetic modulators. The chemopreventive properties and toxicological perspectives of AITCs from the last few decades were taken into account by a number of investigations. Their active therapeutic relevance was hindered by a number of factors, including instability under typical physiological conditions and low bioavailability due to low aqueous solubility. In this review, we highlighted the chemopreventive attributes of AITC in relation to its molecular mechanisms and metabolic fate for cancer. Moreover, we emphasized on investigational anticancer activities and various strategies for delivery of AITC in different types of cancer. Considering cellular interactions, we shed light on the toxicological properties of AITCs to address further issues regarding their assessment in therapeutic development. This review identifies knowledge gaps with various contemporary approaches involving most recent studies and may pave the way for a better understanding for the development of novel AITC therapeutics.
烯丙基异硫氰酸酯（AITC）近年来已被认为是有效的化学治疗和表观遗传调节剂。多项研究考虑了 AITC 在过去几十年中的化学预防特性和毒理学观点。由于其在水中的溶解度低，稳定性差以及生物利用度低，许多因素阻碍了其有效的治疗相关性。在这篇综述中，我们重点介绍了 AITC 在癌症方面的化学预防特性与其分子机制和代谢命运之间的关系。此外，我们强调了 AITC 在不同类型癌症中的抗癌活性及其各种输送策略。考虑到细胞间相互作用，我们阐明了 AITC 的毒理学特性，以解决其在治疗开发中的评估方面的进一步问题。这篇综述确定了与涉及最新研究的各种当代方法相关的知识空白，为新型 AITC 治疗剂的开发铺平了道路。
