Chitkara College of Pharmacy, Chitkkara University, Rajpura, India.
Amity Institute of Pharmacy, Amity University, Noida, India.
Polim Med. 2023 Jan-Jun;53(1):59-68. doi: 10.17219/pim/158009.
The introduction of tablet dosage forms has brought a revolution in the pharmaceutical drug delivery system. Different forms of tablets have been developed based on the target site, the onset of action, and therapeutic drug delivery methods. Fast-disintegrating tablets (FDTs) are the most promising pharmaceutical dosage form, especially for pediatric and geriatric patients having difficulty swallowing. The key feature of FDTs is quick drug release soon after their administration through the oral cavity. With innovations in the formulation of FDTs, the demand for excipients with better functionalities, particularly in terms of flow and compression characteristics, has increased. Co-processed excipients are a mixture of 2 or more conventional excipients that provides significant benefits over the individual excipients while minimizing their shortcomings. Such multifunctional co-processed excipients minimize the number of excipients that are to be incorporated into tablets during the manufacturing process. The present review discusses FTDs formulated from co-processed excipients, their manufacturing techniques, and the latest research, patents and commercially available co-processed FDTs.
片剂剂型的引入给药物传递系统带来了一场革命。根据目标部位、作用开始和治疗药物传递方法，已经开发出了不同形式的片剂。速崩片（FDT）是最有前途的药物剂型，特别是对于吞咽困难的儿科和老年患者。FDT 的关键特征是在通过口腔给药后很快迅速释放药物。随着 FDT 配方的创新，对具有更好功能的赋形剂的需求增加，特别是在流动和压缩特性方面。共处理赋形剂是 2 种或更多常规赋形剂的混合物，在最小化其缺点的同时提供了优于单个赋形剂的显著益处。这种多功能共处理赋形剂可将制造过程中要掺入片剂的赋形剂数量减至最少。本综述讨论了由共处理赋形剂制成的 FDT、它们的制造技术以及最新的研究、专利和市售共处理 FDT。
