同时诊断多发性硬化症和人类免疫缺陷病毒 (HIV) 感染：病例报告及文献复习。
Concomitant diagnosis of multiple sclerosis and human immunodeficiency virus (HIV) infection: case report and the review of literature.
机构信息
Department of Neurosciences, Reproductive Sciences and Odontostomatology, "Federico II" University, Naples, Italy.
Department of Advanced Biomedical Sciences, "Federico II" University, Naples, Italy.
出版信息
Neurol Sci. 2023 Jul;44(7):2305-2309. doi: 10.1007/s10072-023-06727-7. Epub 2023 Mar 17.
BACKGROUND
To date, few cases of multiple sclerosis (MS) patients with concomitant Human Immunodeficiency Virus (HIV) infection have been described. However, none of the previously described cases has been treated with Natalizumab, probably due to the increasing risk of progressive multifocal leukoencephalopathy (PML).
CASE
We report the case of a patient concomitantly diagnosed for HIV infection and MS treated with combined antiretroviral therapy (cART) and Natalizumab for 19 months, without clinical or radiological MS activity.
CONCLUSIONS
Our case might suggest considering Natalizumab in patients with concomitant HIV infection, especially for those with significant disease activity requiring a high efficacy disease modifying treatment.
背景
迄今为止，仅有少数多发性硬化症（MS）合并人类免疫缺陷病毒（HIV）感染患者的病例被描述。然而，由于进行性多灶性白质脑病（PML）的风险增加，以前描述的病例中均未使用那他珠单抗进行治疗。
病例
我们报告了一例同时诊断为 HIV 感染和 MS 的患者，该患者接受了联合抗逆转录病毒疗法（cART）和那他珠单抗治疗 19 个月，无 MS 活动的临床或放射学证据。
结论
我们的病例可能提示考虑在合并 HIV 感染的患者中使用那他珠单抗，尤其是那些疾病活动度高需要高效疾病修正治疗的患者。
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