Department of Biomedical Engineering, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada.
Department of Mechanical and Manufacturing Engineering, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada.
ACS Appl Mater Interfaces. 2023 Mar 29;15(12):16034-16045. doi: 10.1021/acsami.3c00152. Epub 2023 Mar 17.
Hydrogels with different functionalities such as printability, antifreezing properties, adhesion, biocompatibility, and toughness are being continually developed. However, it has been extremely challenging to design adhesive, antifreezing, tough, and biocompatible multifunctional hydrogels with complex shapes simultaneously and prepare them in a short period. In this paper, novel composite hydrogels, which consist of poly(vinyl alcohol) grafted with styrylpyridinium group (PVA-SbQ) and TEMPO-oxidized cellulose nanofibrils (CNF), were successfully synthesized via UV photo-cross-linking. In addition to UV photo-cross-linking, the PVA-SbQ/CNF hydrogels with different shapes could be rapidly printed by facile visible light-based stereolithography printing and laser direct-writing without any photoinitiators in 3 min and 30 s, respectively. The results show that PVA-SbQ/CNF hydrogels are biocompatible because there are no photoinitiators and cross-linkers required during the printing process under visible light. Moreover, the adhesive, antifreezing, mechanical properties, and water-binding capacity of PVA-SbQ/CNF with high-water contents improved significantly as the CNF contents increased. Such hydrogels, which combine multiple advantages, present great potential for application in wound dressings and portable devices with specific requirements for shapes, adhesion, toughness, and tolerance in extreme environments such as dry environments and low temperatures.
正在不断开发具有不同功能的水凝胶，例如可打印性、抗冻性、附着力、生物相容性和韧性。然而，设计具有复杂形状的同时具有粘附性、抗冻性、韧性和生物相容性的多功能水凝胶，并在短时间内制备它们一直极具挑战性。在本文中，通过 UV 光交联成功合成了由接枝有苯乙烯吡啶基团的聚乙烯醇（PVA-SbQ）和 TEMPO 氧化的纤维素纳米纤维（CNF）组成的新型复合水凝胶。除了 UV 光交联之外，通过简单的可见光立体光刻打印和激光直写，无需任何光引发剂，分别在 3 分钟和 30 秒内可快速打印出具有不同形状的 PVA-SbQ/CNF 水凝胶。结果表明，由于在可见光下打印过程中不需要光引发剂和交联剂，因此 PVA-SbQ/CNF 水凝胶具有生物相容性。此外，随着 CNF 含量的增加，高含水量的 PVA-SbQ/CNF 的粘附性、抗冻性、机械性能和水结合能力显著提高。这种具有多种优势的水凝胶在对形状、附着力、韧性和在干燥环境和低温等极端环境中的耐受性有特殊要求的伤口敷料和便携式设备中具有很大的应用潜力。
