Wen Huimei, Tan Jiaying, Tian Mi, Wang Yao, Gao Yanqin, Gong Ye
Department of Critical Care Medicine and Neurosurgery of Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China.
Department of Critical Care Medicine and Neurosurgery of Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China.
Biochem Biophys Res Commun. 2023 Apr 30;654:136-144. doi: 10.1016/j.bbrc.2023.03.007. Epub 2023 Mar 6.
Intracerebral hemorrhage (ICH) is a devastating subtype of stroke characterized by high mortality and morbidity rates with no effective treatment. TGF-β/ALK-5 signaling is reported to participated in the regulation of blood-brain barrier (BBB) integrity in the inflammation pain model, the effects of transforming growth factor (TGF)-β1 and the potential mechanisms on BBB after ICH have not been fully elucidated. Herein, we have demonstrated that peripheral administration of TGF-β1 reduces brain edema and ameliorated BBB injury after ICH. Consistent with previous results, TGF-β1 is shown to promote activation of anti-inflammatory microglia and reduce the inflammatory response after ICH. Furthermore, TGF-β1 administration improves long-term outcomes after ICH. Our data suggest that TGF-β1 may be a promising therapeutic agent for ICH.
脑出血（ICH）是一种破坏性的中风亚型，其特点是死亡率和发病率高，且没有有效的治疗方法。据报道，在炎症性疼痛模型中，TGF-β/ALK-5信号通路参与了血脑屏障（BBB）完整性的调节，但脑出血后转化生长因子（TGF）-β1对血脑屏障的影响及其潜在机制尚未完全阐明。在此，我们证明了外周给予TGF-β1可减轻脑出血后的脑水肿并改善血脑屏障损伤。与先前的结果一致，TGF-β1可促进抗炎性小胶质细胞的激活，并减少脑出血后的炎症反应。此外，给予TGF-β1可改善脑出血后的长期预后。我们的数据表明，TGF-β1可能是一种有前景的脑出血治疗药物。
