HK2：通过调节葡萄糖代谢和线粒体功能来控制小胶质细胞的活性。
HK2: Gatekeeping microglial activity by tuning glucose metabolism and mitochondrial functions.
机构信息
Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao Cancer Institute, Qingdao University, Qingdao, Shandong 266071, China.
Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China.
出版信息
Mol Cell. 2023 Mar 16;83(6):829-831. doi: 10.1016/j.molcel.2023.02.022.
Hexokinase 2 (HK2) plays a multifaceted role in the regulation of cellular activities. A new study by Hu et al. delineated a critical role of HK2 in governing glycolytic flux and mitochondrial activity, thereby modulating microglial functions in maladaptive inflammation in brain diseases.
己糖激酶 2（HK2）在细胞活动的调节中发挥着多方面的作用。胡等人的一项新研究阐明了 HK2 在调节糖酵解通量和线粒体活性方面的关键作用，从而调节脑疾病中小胶质细胞功能的适应性炎症。
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