麻醉学研究中的旋转与脆弱性：当警报声传入麻醉医生耳中时。

Spin and fragility in anaesthesia studies: when sirens sing into anaesthetists' ears.

作者信息

Gama de Abreu Marcelo, Schultz Marcus J, Serpa Neto Ary

机构信息

Department of Outcomes Research, Cleveland, OH, USA; Department of Intensive Care and Resuscitation, Cleveland, OH, USA; Department of Cardiothoracic Anesthesiology, Cleveland Clinic, Cleveland, OH, USA; Department of Anesthesiology and Intensive Care, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.

Department of Intensive Care, Amsterdam University Medical Centre, Location AMC, Amsterdam, the Netherlands; Mahidol-Oxford Tropical Medicine Research Unit (MORU), Mahidol University, Bangkok, Thailand; Nuffield Department of Medicine, University of Oxford, Oxford, UK.

出版信息

Br J Anaesth. 2023 May;130(5):507-510. doi: 10.1016/j.bja.2023.02.021. Epub 2023 Mar 15.

DOI:10.1016/j.bja.2023.02.021

PMID:36931963

Abstract

Spin and fragility are common in randomised controlled trials published in anaesthesia journals. Staying with the facts and addressing only the primary endpoint in the conclusion of clinical research reports might help reduce spin. Routinely reporting the fragility index, in turn, could deliver information about robustness, enhancing the transparency of positive dichotomous results. It is in the best interest of clinical research that authors, reviewers, and journals come together to reduce spin and address the fragility of randomised controlled trials.

摘要

在麻醉学杂志上发表的随机对照试验中，夸大和脆弱性很常见。坚持事实并仅在临床研究报告的结论中提及主要终点可能有助于减少夸大。反过来，常规报告脆弱性指数可以提供有关稳健性的信息，提高阳性二分结果的透明度。作者、审稿人和期刊共同努力以减少夸大并解决随机对照试验的脆弱性，这符合临床研究的最大利益。