氯氮平是否通过纹状体中的谷氨酸调节来治疗抗精神病药引起的行为超敏反应？
Does clozapine treat antipsychotic-induced behavioural supersensitivity through glutamate modulation within the striatum?
机构信息
Cramond Clinic, The Queen Elizabeth Hospital, Woodville South, SA, 5011, Australia.
Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia.
出版信息
Mol Psychiatry. 2023 May;28(5):1839-1842. doi: 10.1038/s41380-023-02026-x. Epub 2023 Mar 17.
Abstract
Behavioural supersensitivity may be a result of increased glutamate sensitivity of D2-MSN and reduced sensitivity to dopamine. We propose that clozapine may address behavioural supersensitivity by modulating glutamate activity which may partially explain its unique effectiveness in the setting of treatment resistant schizophrenia.
摘要
行为超敏可能是由于 D2-MSN 谷氨酸敏感性增加和对多巴胺敏感性降低所致。我们提出氯氮平可能通过调节谷氨酸活性来解决行为超敏问题，这可能部分解释了其在治疗抵抗性精神分裂症中的独特疗效。
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