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阿莫西林和卡马西平对海洋桡足类桡足动物的单独和联合作用。

Individual and combined effects of amoxicillin and carbamazepine to the marine copepod Tigriopus fulvus.

机构信息

National Research Council, Water Research Institute (IRSA-CNR), Via Roma, 3, 74123, Taranto, Italy.

Department of Chemical Sciences and Technologies, University of Rome "Tor Vergata", Via Della Ricerca Scientifica, 1 - 00133, Rome, Italy.

出版信息

Environ Sci Pollut Res Int. 2023 May;30(22):61672-61681. doi: 10.1007/s11356-023-26498-0. Epub 2023 Mar 18.

DOI:10.1007/s11356-023-26498-0
PMID:36933130
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10167106/
Abstract

Pharmaceuticals can be considered a global threat to aquatic ecosystems due to their pseudo-persistence and their potential toxicity towards non-target species. Amoxicillin (AMX) and carbamazepine (CBZ) and their mixture (1:1) were investigated on the marine copepod Tigriopus fulvus (Fischer, 1860) considering both acute and chronic endpoints. While acute and chronic exposure did not directly affect survival, reproductive endpoints were affected like the mean egg hatching time that was significantly longer than the negative control for treatments with AMX (0.789 ± 0.079 μg/L), CBZ (8.88 ± 0.89 μg/L), and AMX and CMZ as a mixture (1.03 ± 0.10 μg/L and 0.941 ± 0.094 μg/L), in that order.

摘要

由于其假持久性和对非靶标物种的潜在毒性，药品被认为是对水生生态系统的全球性威胁。本研究采用海洋桡足类桡足类三刺真猛水蚤（Fischer，1860）为实验生物，考察了阿莫西林（AMX）和卡马西平（CBZ）及其混合物（1:1）的急性和慢性毒性。急性和慢性暴露虽然没有直接影响生存，但对繁殖终点有影响，例如平均卵孵化时间显著长于阴性对照组，在 AMX（0.789±0.079μg/L）、CBZ（8.88±0.89μg/L）和 AMX 和 CBZ 混合物（1.03±0.10μg/L 和 0.941±0.094μg/L）处理组中均如此。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a7c/10167106/6046a5da50e8/11356_2023_26498_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a7c/10167106/9aa148e46627/11356_2023_26498_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a7c/10167106/94fae17a1350/11356_2023_26498_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a7c/10167106/6046a5da50e8/11356_2023_26498_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a7c/10167106/9aa148e46627/11356_2023_26498_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a7c/10167106/94fae17a1350/11356_2023_26498_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a7c/10167106/6046a5da50e8/11356_2023_26498_Fig3_HTML.jpg

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