Altern Ther Health Med. 2023 May;29(4):170-176.
To investigate the value of comprehensive rehabilitation therapy in chronic obstructive pulmonary disease (COPD) and its effect on improvement in patients' inflammation.
A total of 174 patients with acute COPD exacerbation in the Affiliated Hospital of Hebei University in China from March 2020 to January 2022 were selected as research subjects. They were divided into control, acute and stable groups according to the random number table method (n=58 in each group). The control group was given conventional treatment; the acute group started comprehensive rehabilitation treatment in the acute phase; in the stable group, comprehensive rehabilitation treatment was initiated in the stable period after the condition was stabilized with conventional treatment. Tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6) and pulmonary function were measured before and after treatment, with the forced expiratory volume in 1 second (FEV1), forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) ratio, and peak expiratory flow rate (PEF). A 6-min walk test (6MWD) was performed on the patient, and the ability to perform activities of daily living (ADL), self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were used to assess patients' ability to perform ADL and psychology. Finally, the incidence of adverse events (AEs) in patients was recorded and a quality of life (QoL) survey was completed.
The 6MWD test, ADL, FEV1, FEV1/FVC and PEF were elevated in the acute and stable groups compared with the control group, whereas shortness of breath, TNF-α, hs-CRP and IL-6 were decreased (P < .05). SAS and SDS scores were reduced in the acute and stable groups after treatment (P < .05), while there was no change in the control group (P > .05). In addition, QoL was higher in the acute and stable groups (P < .05). The improvement of all indicators in the acute group was better than in the stable group (P < .05).
Comprehensive rehabilitation therapy can improve the exercise capacity and lung function of patients with COPD, reduce inflammation, and improve patients' negative psychology.
探讨综合康复疗法在慢性阻塞性肺疾病（COPD）中的应用价值及其对改善患者炎症的作用。
选取 2020 年 3 月至 2022 年 1 月河北大学附属医院收治的急性 COPD 加重期患者 174 例作为研究对象，采用随机数字表法分为对照组、急性组和稳定组，每组 58 例。对照组给予常规治疗；急性组在急性发作期开始综合康复治疗；稳定组在常规治疗稳定病情后进入稳定期开始综合康复治疗。治疗前后检测肿瘤坏死因子-α（TNF-α）、高敏 C 反应蛋白（hs-CRP）、白细胞介素-6（IL-6）及肺功能，用力肺活量占预计值百分比（FEV1%）、1 秒用力呼气容积占预计值百分比（FEV1/FVC）、呼气峰流速（PEF）。对患者进行 6 分钟步行试验（6MWD），采用日常生活活动能力量表（ADL）、焦虑自评量表（SAS）和抑郁自评量表（SDS）评估患者的日常生活活动能力和心理状况。记录患者不良反应（AE）发生情况，完成生活质量（QoL）调查。
急性组和稳定组 6MWD 试验、ADL、FEV1、FEV1/FVC、PEF 高于对照组，呼吸困难、TNF-α、hs-CRP、IL-6 低于对照组（P<0.05）。急性组和稳定组治疗后 SAS、SDS 评分低于治疗前（P<0.05），对照组治疗前后差异无统计学意义（P>0.05）。急性组和稳定组 QoL 评分高于对照组（P<0.05）。急性组各指标改善均优于稳定组（P<0.05）。
综合康复疗法可提高 COPD 患者运动能力和肺功能，减轻炎症反应，改善患者负面心理。
