Department of Biology, University of Turku, 20014 Turku, Finland.
Department of Immunology, Tehran University of Medical Sciences, Tehran, Iran.
Neurotoxicology. 2023 May;96:154-165. doi: 10.1016/j.neuro.2023.03.003. Epub 2023 Mar 16.
Although anxiety disorders, as well as difficulties in social interaction, are documented in children with autism spectrum disorder (ASD) as a neurodevelopmental disorder, the effectiveness of potential therapeutic procedures considering age and sex differences is under serious discussion. The present study aimed to investigate the effect of resveratrol (RSV) on anxiety-like behaviors and social interaction in juvenile and adult rats of both sex in a valproic acid (VPA)-induced autistic-like model. Prenatal exposure to VPA was associated with increased anxiety, also causing a significant reduction in social interaction in juvenile male subjects. Further administration of RSV attenuated VPA-induced anxiety symptoms in both sexes of adult animals and significantly increased the sociability index in male and female juvenile rats. Taken together, it can be concluded that treatment with RSV can attenuate some of the harsh effects of VPA. This treatment was especially effective on anxiety-like traits in adult subjects of both sexes regarding their performance in open field and EPM. We encourage future research to consider the sex and age-specific mechanisms behind the RSV treatment in the prenatal VPA model of autism.
尽管焦虑障碍以及社交互动困难在自闭症谱系障碍（ASD）儿童中被记录为神经发育障碍，但考虑到年龄和性别差异的潜在治疗程序的有效性仍在激烈讨论中。本研究旨在调查白藜芦醇（RSV）对 VPA 诱导的自闭症样模型中幼年和成年雄性和雌性大鼠的焦虑样行为和社交互动的影响。产前暴露于 VPA 与焦虑增加有关，还导致幼年雄性动物的社交互动显著减少。进一步给予 RSV 可减轻成年动物两性的 VPA 诱导的焦虑症状，并显著增加幼年雄性和雌性大鼠的社交指数。总之，可以得出结论，RSV 治疗可以减轻 VPA 的一些严重影响。这种治疗对两性成年动物的焦虑样特征特别有效，因为它们在旷场和 EPM 中的表现。我们鼓励未来的研究考虑 RSV 治疗在自闭症产前 VPA 模型中的性别和年龄特异性机制。
