Malatya Turgut Ozal University, Akcadag Vocational School, Laboratory and Veterinary Health Program, Akcadag, Malatya, Turkey.
Iskenderun Technical University Iskenderun Vocational School, Environmental Protection and Control Program, Iskenderun, Hatay, Turkey; Inonu University, Faculty of Engineering, Department of Mining Engineering, Malatya, Turkey.
Chemosphere. 2023 Jun;325:138342. doi: 10.1016/j.chemosphere.2023.138342. Epub 2023 Mar 16.
Titanium dioxide is used in many commercial and industrial areas such as paint, paper, cosmetics, textiles, and surface coating. The reasons for its use in such a wide area are its anti-corrosion and high stability. Although TiO is considered to be a low-toxicity material, research has been further expanded following the recognition of the possible carcinogenic effects of TiO in humans by the International Agency for Research on Cancer (IARC). The aim of this study is to compare the toxicity of TiO used in many fields in different phases. In the study anatase TiO synthesized by hydrothermal method and dual phase TiO (anatase and rutile phase) structures obtained by thermal conditioning were used and compared with commercially available TiO. ZnO which has similar uses like TiO was also used and compared with 1% doped TiO in different phases in terms of toxicity. Zebrafish (Danio rerio, D. rerio), a freshwater fish, which is widely used in toxicity assessments was preferred in this study due to its small size, fast reproduction rate, low cost, physiological and molecular similarity with humans, and genetic predisposition. Experimental investigations showed that the highest death occurred in the low concentrations of (10 ppm) ZnO doped rutile phase. 39% of the embryos died in the ZnO nanoparticle solutions prepared at low concentrations. The highest mortality at medium (100 ppm) and high (1000 ppm) concentrations were observed in the ZnO-doped rutile phase after 96 h. Similarly, the highest malformation was detected in the ZnO-doped rutile phase during the same period.
二氧化钛在许多商业和工业领域中得到广泛应用，如涂料、纸张、化妆品、纺织品和表面涂层。它在如此广泛的领域中被使用的原因是其具有抗腐蚀性和高稳定性。尽管 TiO 被认为是一种低毒性物质，但在国际癌症研究机构（IARC）认识到 TiO 对人类可能具有致癌作用之后，对其的研究进一步扩展了。本研究旨在比较不同阶段在许多领域中使用的 TiO 的毒性。在研究中，使用了水热法合成的锐钛矿 TiO 和通过热条件获得的双相 TiO（锐钛矿和金红石相）结构，并与市售 TiO 进行了比较。还使用了与 TiO 具有相似用途的 ZnO，并在不同相中与 1%掺杂的 TiO 进行了毒性比较。由于其体积小、繁殖速度快、成本低、与人类的生理和分子相似性以及遗传倾向，本研究中选择了淡水鱼斑马鱼（Danio rerio，D. rerio）作为毒性评估的模型。实验研究表明，在低浓度（10 ppm）的 ZnO 掺杂金红石相中，死亡率最高。在低浓度下制备的 ZnO 纳米粒子溶液中，有 39%的胚胎死亡。在 96 小时后，在中浓度（100 ppm）和高浓度（1000 ppm）的 ZnO 掺杂金红石相中观察到最高死亡率。同样，在同一时期，在 ZnO 掺杂金红石相中检测到最高的畸形率。
