de Liz Laryssa Vanessa, Stoco Patrícia Hermes, Sunter Jack D
Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK.
Trends Parasitol. 2023 May;39(5):332-344. doi: 10.1016/j.pt.2023.02.009. Epub 2023 Mar 16.
A key morphological feature of kinetoplastid parasites is the position and length of flagellum attachment to the cell body. This lateral attachment is mediated by the flagellum attachment zone (FAZ), a large complex cytoskeletal structure, which is essential for parasite morphogenesis and pathogenicity. Despite the complexity of the FAZ only two transmembrane proteins, FLA1 and FLA1BP, are known to interact and connect the flagellum to the cell body. Across the different kinetoplastid species, each only has a single FLA/FLABP pair, except in Trypanosoma brucei and Trypanosoma congolense where there has been an expansion of these genes. Here, we focus on the selection pressure behind the evolution of the FLA/FLABP proteins and the likely impact this will have on host-parasite interactions.
动质体寄生虫的一个关键形态特征是鞭毛附着于细胞体的位置和长度。这种横向附着由鞭毛附着区（FAZ）介导，FAZ是一种大型复杂的细胞骨架结构，对寄生虫的形态发生和致病性至关重要。尽管FAZ很复杂，但已知只有两种跨膜蛋白FLA1和FLA1BP相互作用并将鞭毛连接到细胞体。在不同的动质体物种中，除了布氏锥虫和刚果锥虫中这些基因发生了扩增外，每种物种只有一对FLA/FLABP。在这里，我们关注FLA/FLABP蛋白进化背后的选择压力以及这可能对宿主-寄生虫相互作用产生的影响。
