抗 MNS 血型系统中冷反应性免疫球蛋白 G 抗体 M 导致胎儿溶血病。
Maternal Cold-Reacting Immunoglobulin G Anti-M of MNS Blood Group System Causing Hemolytic Disease of the Fetus.
机构信息
Shenzhen Institute of Transfusion Medicine, Shenzhen Blood Center, Shenzhen, Guangdong, China.
Department of Biomedical Sciences, City University of Hong Kong, Hong Kong SAR, China.
出版信息
Iran J Immunol. 2023 Mar 14;20(1):129-134. doi: 10.22034/iji.2023.93993.2273.
Several cases of the hemolytic disease of the fetus and newborn (HDFN) caused by immunoglobulin G (IgG) anti-M antibodies have been reported, in which almost all the HDFN-associated anti-M were warmly reacting. Here we report two cases of severe HDFN associated with cold-reacting IgG anti-M. In both cases, pregnancy was terminated, in weeks 33 and 23 respectively, due to a diagnosis of fetal growth retardation (FGR). To our knowledge, these are the most severe HDFN cases caused by cold-reacting IgG anti-M.
已经报道了几例由免疫球蛋白 G（IgG）抗-M 抗体引起的胎儿和新生儿溶血病（HDFN），其中几乎所有与 HDFN 相关的抗-M 均呈温暖反应。在这里，我们报告了两例与冷反应性 IgG 抗-M 相关的严重 HDFN 病例。在这两种情况下，由于胎儿生长迟缓（FGR）的诊断，妊娠分别在第 33 周和第 23 周终止。据我们所知，这些是由冷反应性 IgG 抗-M 引起的最严重的 HDFN 病例。
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