内毒素诱导家兔体内华法林药代动力学的变化。
Endotoxin induced changes in the pharmacokinetics of warfarin in rabbits.
作者信息
Ladefoged O
出版信息
Acta Vet Scand. 1978;19(4):479-86. doi: 10.1186/BF03547587.
Abstract
The action of bacterial endotoxin on the pharmacokinetics of warfarin was investigated in rabbits injected with bacterial endotoxin from E. coli. High doses of endotoxin were able to change the kinetics of warfarin in rabbits by changing its volume of distribution. It is not possible to conclude whether the changes in elimination rate of warfarin in rabbits were mediated through changes in liver blood flow or through impairment of the metabolic capacity of the liver cells.
摘要
在注射了大肠杆菌细菌内毒素的兔子身上，研究了细菌内毒素对华法林药代动力学的作用。高剂量的内毒素能够通过改变华法林的分布容积来改变其在兔子体内的动力学。目前尚无法确定兔子体内华法林消除率的变化是通过肝血流量的改变还是肝细胞代谢能力的损害介导的。
相似文献
1
Endotoxin induced changes in the pharmacokinetics of warfarin in rabbits.内毒素诱导家兔体内华法林药代动力学的变化。
Acta Vet Scand. 1978;19(4):479-86. doi: 10.1186/BF03547587.
2
The effect of E. coli endotoxin on cardiac and skeletal muscle myofibrillar ATPase.大肠杆菌内毒素对心肌和骨骼肌肌原纤维ATP酶的作用。
Biochem Med. 1973 Aug;8(1):11-7. doi: 10.1016/0006-2944(73)90003-3.
3
[Effects of coli endotoxin on some enzymatic systems of the body: anticholinesterase activity].[大肠杆菌内毒素对机体某些酶系统的影响：抗胆碱酯酶活性]
Fiziol Norm Patol. 1968 Jan-Feb;14(1):81-6.
4
[Histopathological changes in the organs of rabbits with experimental shock induced by an endotoxin of E. coli].
Zhonghua Bing Li Xue Za Zhi. 1986 Jun;15(2):140-2.
5
6
The effect of Escherichia coli endotoxin on extracellular fluid volume.大肠杆菌内毒素对细胞外液量的影响。
Br J Surg. 1970 May;57(5):380.
7
In vitro and in vivo effect of Escherichia coli endotoxin on mitochondrial phospholipase A2 activity.大肠杆菌内毒素对线粒体磷脂酶A2活性的体外和体内效应。
FEBS Lett. 1981 May 5;127(1):115-20. doi: 10.1016/0014-5793(81)80355-9.
8
[Ultrastructural features of changes in capillaries and atrial cardiomyocytes induced by endotoxin injection].[内毒素注射诱导的毛细血管和心房心肌细胞变化的超微结构特征]
Tsitol Genet. 1992 Mar-Apr;26(2):17-20.
9
Functional and morphological effects of endotoxin on the reticuloendothelial system. A contribution to the etiopathogenesis of shock.
Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove. 1976;19(2):125-63.
10
Myocardial fatty acid and lactate metabolism after E. coli endotoxin administration.大肠杆菌内毒素给药后心肌脂肪酸和乳酸代谢
Circ Shock. 1977;4(2):191-200.
引用本文的文献
1
Disposition kinetics of erythromycin in normal and experimentally-induced febrile rabbits.
Eur J Drug Metab Pharmacokinet. 1999 Apr-Jun;24(2):127-32. doi: 10.1007/BF03190357.
2
The effect of carbon tetrachloride (CCl4) induced liver damage on the volume of distribution, the elimination half-life and body clearance of antipyrine and warfarin in rabbits.四氯化碳（CCl₄）诱导的肝损伤对兔体内安替比林和华法林的分布容积、消除半衰期及体内清除率的影响。
Acta Vet Scand. 1979;20(3):429-37. doi: 10.1186/BF03546604.
本文引用的文献
1
The influence of pyrogen-induced fever on salicylamide metabolism in man.致热原引起的发热对人体水杨酰胺代谢的影响。
J Clin Invest. 1972 Nov;51(11):2959-66. doi: 10.1172/JCI107120.
2
The reaction of different animal species to bacterial pyrogens.不同动物物种对细菌热原的反应。
Zentralbl Veterinarmed A. 1968;15(6):532-43. doi: 10.1111/j.1439-0442.1968.tb00456.x.
3
Editorial: Gram-negative-rod bacteremia.
N Engl J Med. 1974 Oct 3;291(14):733-4. doi: 10.1056/NEJM197410032911411.
4
Effects of etiocholanolone-induced fever on plasma antipyrine half-lives and metabolic clearance.表雄酮诱导的发热对血浆安替比林半衰期及代谢清除率的影响。
Clin Pharmacol Ther. 1975 Apr;17(4):447-57. doi: 10.1002/cpt1975174447.
5
Pharmacokinetics in patients with cardiac failure.心力衰竭患者的药代动力学。
Clin Pharmacokinet. 1976 Nov-Dec;1(6):389-405. doi: 10.2165/00003088-197601060-00001.
6
Hepatic microsomal drug metabolism after administration of endotoxin in rats.大鼠内毒素给药后肝微粒体药物代谢
Biochem Pharmacol. 1976 Feb 1;25(3):351-3. doi: 10.1016/0006-2952(76)90226-4.
7
Pharmacokinetics of trimethoprim (TMP) in normal and febrile rabbits.甲氧苄啶（TMP）在正常及发热家兔体内的药代动力学
Acta Pharmacol Toxicol (Copenh). 1977 Nov;41(5):507-14. doi: 10.1111/j.1600-0773.1977.tb02162.x.
8
Protein binding of coumarin anticoagulants in disease states.疾病状态下香豆素类抗凝剂的蛋白结合情况。
Clin Pharmacokinet. 1977 Mar-Apr;2(2):110-26. doi: 10.2165/00003088-197702020-00003.
9
Drug metabolism under pathological and abnormal physiological states in animals and man.动物和人类在病理及异常生理状态下的药物代谢。
Xenobiotica. 1977 Jan-Feb;7(1-2):25-92. doi: 10.3109/00498257709036242.
Zotero 插件