内毒素诱导家兔体内华法林药代动力学的变化。
Endotoxin induced changes in the pharmacokinetics of warfarin in rabbits.
作者信息
Ladefoged O
出版信息
Acta Vet Scand. 1978;19(4):479-86. doi: 10.1186/BF03547587.
Abstract
The action of bacterial endotoxin on the pharmacokinetics of warfarin was investigated in rabbits injected with bacterial endotoxin from E. coli. High doses of endotoxin were able to change the kinetics of warfarin in rabbits by changing its volume of distribution. It is not possible to conclude whether the changes in elimination rate of warfarin in rabbits were mediated through changes in liver blood flow or through impairment of the metabolic capacity of the liver cells.
摘要
在注射了大肠杆菌细菌内毒素的兔子身上，研究了细菌内毒素对华法林药代动力学的作用。高剂量的内毒素能够通过改变华法林的分布容积来改变其在兔子体内的动力学。目前尚无法确定兔子体内华法林消除率的变化是通过肝血流量的改变还是肝细胞代谢能力的损害介导的。
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