Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, MSC 861, Charleston, SC 29425, United States of America.
Psychiatry and Behavioral Sciences, Medical University of South Carolina, 67 President Street, MSC 861, Charleston, SC 29425, United States of America.
Gen Hosp Psychiatry. 2023 May-Jun;82:41-46. doi: 10.1016/j.genhosppsych.2023.03.003. Epub 2023 Mar 14.
The purpose was to examine associations between HIV care engagement and mental health symptoms among persons living with HIV (PLWH) receiving ART. This study builds upon previous findings indicating a significant association between mental health and retention in HIV care, while also advancing the literature by examining the impact of substance use on this link, as well as potential bidirectional associations.
Participants of the current study were 493 patients who engaged in care and received antiviral therapy (ART) from Infectious Disease physicians between 2017 and 2019 in a large academic medical center.
Results from hierarchical regression analyses revealed that patients who missed more days of ART medication had higher depressive symptoms, even when accounting for the effect of demographic variables and alcohol use. Further, depressive symptoms predicted significant variance in number of "no show" visits, but was not individually predictive of ""no show"" visits beyond the effect of other HIV care outcomes (e.g., number of days of medication missed).
Findings reflect linkages among HIV treatment adherence, mental health, and substance use, and highlight the need to target mental health symptoms to improve outcomes among PLWH and prevent HIV transmission.
本研究旨在探讨接受抗逆转录病毒治疗（ART）的 HIV 感染者（PLWH）的 HIV 护理参与度与心理健康症状之间的关联。本研究基于先前的研究结果，这些结果表明心理健康与 HIV 护理的保留之间存在显著关联，同时通过检查物质使用对这一关联的影响，以及潜在的双向关联，推进了文献研究。
本研究的参与者是 2017 年至 2019 年期间在一家大型学术医疗中心接受传染病医生护理和抗病毒治疗（ART）的 493 名患者。
分层回归分析的结果表明，即使考虑到人口统计学变量和酒精使用的影响，错过更多天 ART 药物的患者抑郁症状也更高。此外，抑郁症状可预测“失约”就诊次数的显著差异，但除了其他 HIV 护理结果（例如错过的药物天数）的影响外，抑郁症状并不能单独预测“失约”就诊次数。
研究结果反映了 HIV 治疗依从性、心理健康和物质使用之间的联系，并强调需要针对心理健康症状，以改善 PLWH 的治疗结果并预防 HIV 传播。
