Department of Rheumatology, Reina Sofia University Hospital, Cordoba, Spain; GC05 group, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Cordoba, Spain.
Department of Rheumatology, Reina Sofia University Hospital, Cordoba, Spain; GC05 group, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Cordoba, Spain; Department of Medical and Surgical Sciences, University of Cordoba, Cordoba, Spain.
Joint Bone Spine. 2023 Jul;90(4):105563. doi: 10.1016/j.jbspin.2023.105563. Epub 2023 Mar 17.
The objective was to evaluate the association between the age at onset of psoriatic arthritis (PsA) symptoms with the characteristics and burden of the disease.
This was an observational and cross-sectional study that included a subgroup of 231 patients with PsA with < 10 years of disease duration from the REGISPONSER and RESPONDIA registries. Patients were divided into two groups according to the age of PsA symptom onset (early onset: ≤ 40-years-old and late onset: ≥ 60-years-old). The characteristics and burden of the disease were compared between the two groups, and multivariate logistic regression was performed to determine the factors independently associated with late-onset PsA.
Patients from the early-onset group showed a significantly lower prevalence of males [94 (62.3%) vs. 38 (86.4%)] and a higher prevalence of enthesitis [44 (24.6%) vs. 5 (9.8%)] and sacroiliitis [30 (16.8%) vs. 4 (7.7%)]. Additionally, the early-onset group showed lower scores on the BASFI [2.2 (2.2) vs. 3.3 (2.5)] and minor structural damage (BASRI) in both the spine [1.6 (2) vs. 2.9 (3)] and whole axial skeleton (total BASRI) [1.9 (2.4) vs. 3.4 (3.4)]. In contrast, no statistically significant differences were found between the groups in disease activity evaluated by the BASDAI and ASDAS. Logistic regression analysis showed that late-onset PsA was independently associated with being male (OR 4.4, 95% CI: 1.3, 16.3), greater structural damage (total BASRI) (OR 3.3, 95% CI: 1.3, 8.1), a higher frequency of arthritis in the upper limbs (OR 2.8, 95% CI: 1, 7.7), and greater loss of function (BASFI) (OR 1.3, 95% CI: 1, 1.6).
Patients with late-onset PsA showed different clinical characteristics and greater disease severity than those with early-onset PsA.
评估银屑病关节炎（PsA）症状发病年龄与疾病特征和负担之间的关系。
这是一项观察性和横断面研究，纳入了 REGISPONSER 和 RESPONDIA 登记处中 231 例病程<10 年的 PsA 亚组患者。根据 PsA 症状发病年龄（早发：≤40 岁和晚发：≥60 岁）将患者分为两组。比较两组间疾病特征和负担，采用多变量逻辑回归确定与晚发 PsA 相关的独立因素。
早发组患者男性比例显著较低[94（62.3%）比 38（86.4%）]，附着点炎[44（24.6%）比 5（9.8%）]和骶髂关节炎[30（16.8%）比 4（7.7%）]发生率较高。此外，早发组 BASFI 评分[2.2（2.2）比 3.3（2.5）]和脊柱[1.6（2）比 2.9（3）]和整个轴向骨骼（总 BASRI）[1.9（2.4）比 3.4（3.4）]的结构损伤较小。然而，两组在 BASDAI 和 ASDAS 评估的疾病活动方面无统计学差异。逻辑回归分析表明，晚发 PsA 与男性（OR 4.4，95%CI：1.3，16.3）、更大的结构损伤（总 BASRI）（OR 3.3，95%CI：1.3，8.1）、上肢关节炎更频繁（OR 2.8，95%CI：1，7.7）和功能丧失更大（BASFI）（OR 1.3，95%CI：1，1.6）相关。
与早发 PsA 患者相比，晚发 PsA 患者表现出不同的临床特征和更严重的疾病。
