Department of Surgery and Cancer, Imperial College London, London, UK; Imperial Vascular Unit, Imperial College Healthcare NHS Trust, London, UK.
Medical Data Research Collaborative, London, UK; Department of Plastic Surgery, Salisbury NHS Foundation Trust, Salisbury, UK.
Eur J Vasc Endovasc Surg. 2023 Jul;66(1):68-76. doi: 10.1016/j.ejvs.2023.03.015. Epub 2023 Mar 17.
To assess trends in abdominal aortic aneurysm (AAA) hospital admissions, interventions, and aneurysm related mortality in England, and to examine the impact of endovascular repair on mortality for the years 1998 - 2020.
Hospital admission and operative approach (endovascular aortic aneurysm repair, or open surgical repair [OSR]) using Hospital Episodes Statistics (HES), and aneurysm related mortality data from the Office for National Statistics for England standardised to the 2013 European Standard Population, were analysed using linear regression and Joinpoint regression analyses. Aneurysm related mortality was compared between the pre-endovascular era (1998 - 2010) and the endovascular era (2011 - 2019).
A declining trend in hospital admission incidence was observed, mainly due to a decline in ruptured admissions from 34.6 per 100 000 (95% confidence interval [CI] 33.5 - 35.6) to 13.5 per 100 000 (95% CI 12.9 - 14.2; β = -1.04, r = .97, p < .001). Operative interventions have been declining over the last 23 years mainly due to the statistically significant decline in open procedures (41.2 per 100 000 in 2000 [95% CI 40 - 42.3] to 9.6 per 100 000 [95% CI 9.1 - 10.1]; β = -1.92, r = .95; p < .001). There was an increasing trend toward endovascular procedures (5.8 per 100 000 [95% CI 5.3 - 6.2] in 2006 to 16.9 per 100 000 [95% CI 16.2 - 17.5] in 2020; β = .82, r = .30, p = .040). Reductions in aneurysm related mortality due to AAAs were observed for males and females, irrespective of age and rupture status.
A significant decrease in hospital admissions for AAAs was observed over the last 23 years in England, paralleled by a shift toward endovascular repair and a decline in OSR. Declines in aneurysm related mortality were observed overall, and in the endovascular era irrespective of age, sex, and rupture status.
评估英格兰腹主动脉瘤(AAA)住院治疗、介入治疗和与动脉瘤相关的死亡率的趋势,并研究血管内修复对 1998 年至 2020 年期间死亡率的影响。
利用医院入院和手术方式(血管内主动脉瘤修复或开放手术修复[OSR])的医院入院数据(使用医院发病统计数据[HES]),以及与动脉瘤相关的死亡率数据,这些数据来自英国国家统计局,按照 2013 年欧洲标准人口进行了标准化,使用线性回归和 Joinpoint 回归分析进行了分析。在血管内修复前时代(1998-2010 年)和血管内修复时代(2011-2019 年)之间比较了与动脉瘤相关的死亡率。
观察到住院发病率呈下降趋势,主要是由于破裂性入院人数从每 100000 人 34.6 人(95%置信区间[CI] 33.5-35.6)下降至每 100000 人 13.5 人(95%CI 12.9-14.2;β=-1.04,r=.97,p<.001)。在过去的 23 年中,手术干预一直在下降,主要是由于开放手术的数量出现了统计学上的显著下降(2000 年每 100000 人 41.2 人[95%CI 40-42.3]至每 100000 人 9.6 人[95%CI 9.1-10.1];β=-1.92,r=.95;p<.001)。血管内手术的趋势呈上升趋势(2006 年每 100000 人 5.8 人[95%CI 5.3-6.2]至 2020 年每 100000 人 16.9 人[95%CI 16.2-17.5];β=.82,r=.30,p=.040)。无论年龄和破裂情况如何,男性和女性的与动脉瘤相关的死亡率均有所下降。
在过去的 23 年中,英格兰的 AAA 住院治疗显著减少,同时手术方式向血管内修复转变,开放手术减少。总体上观察到与动脉瘤相关的死亡率下降,并且在血管内修复时代,无论年龄、性别和破裂状态如何,死亡率都在下降。