MOE Key laboratory of Cluster Science Key Laboratory of Medical Molecule Science and Pharmaceutical Engineering School of Chemistry and Chemical Engineering, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian, Beijing, 100081, China.
Chemistry. 2023 Jun 2;29(31):e202300004. doi: 10.1002/chem.202300004. Epub 2023 Apr 24.
Biomimetic synthesis of guanine crystals has been focused on in the last years. However, multi-functional guanine crystals occluded with fluorescent molecules have not been realized in the laboratory. Here, the controllable synthesis of guanine crystal microplatelets with fluorescence and pearlescence was achieved for the first time by incorporating Nile red (NR) or fluorescein isothiocyanate (FITC) molecules into guanine crystals. The synthesized fluorescent guanine crystals are pure β-phase anhydrous guanine single crystals. Aqueous suspensions with NR- and FITC-doped guanine crystals exhibit distinct pearlescence. The fluorescence intensities of NR and FITC were greatly enhanced after being doped into guanine crystals due to the inhibition of aggregation-caused quenching. Moreover, films composed of fluorescent guanine microplatelets exhibit high diffuse reflection intensity (70 %). This work provides a strategy to synthesize multifunctional materials composed of organic crystals occluded with dyes.
近年来，人们一直专注于生物模拟合成鸟嘌呤晶体。然而，在实验室中尚未实现具有荧光分子的多功能鸟嘌呤晶体。在这里，首次通过将尼罗红（NR）或异硫氰酸荧光素（FITC）分子掺入鸟嘌呤晶体中，实现了具有荧光和珍珠光泽的鸟嘌呤晶体微板的可控合成。合成的荧光鸟嘌呤晶体是纯β相无水鸟嘌呤单晶。含有 NR 和 FITC 的鸟嘌呤晶体的水悬浮液表现出明显的珍珠光泽。由于抑制了聚集诱导猝灭，NR 和 FITC 的荧光强度在掺杂到鸟嘌呤晶体后大大增强。此外，由荧光鸟嘌呤微板组成的薄膜表现出高漫反射强度（70%）。这项工作提供了一种合成由染料封闭的有机晶体组成的多功能材料的策略。
