成纤维细胞生长因子 21 和生长分化因子 15 在偏头痛中增加，并与偏头痛相关残疾的严重程度相关。
FGF-21 and GDF-15 are increased in migraine and associated with the severity of migraine-related disability.
机构信息
Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, No 88 Jiefang Road, Hangzhou, Zhejiang, China.
Department of Anesthesiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, No 88 Jiefang Road, Hangzhou, Zhejiang, China.
出版信息
J Headache Pain. 2023 Mar 20;24(1):28. doi: 10.1186/s10194-023-01563-8.
BACKGROUND
Migraine is a prevalent disorder with significant socioeconomic impact. The impairment of metabolic homeostasis in migraine warrants further investigation. Changes in serum levels of Fibroblast-growth-factor 21 (FGF-21) and Growth-differentiation-factor 15 (GDF-15) are characteristic of some metabolic and mitochondrial diseases. This study aimed to assess whether the presence of migraine affects serum levels of FGF-21 and GDF-15, and taking metabolic disorders into account as potential confounding factors.
METHODS
We collected serum samples from 221 migraine patients (153 episodic migraineurs and 68 chronic migraineurs) and 124 healthy controls. The serum concentrations of FGF-21 and GDF-15 were measured using an enzyme-linked immunosorbent assay (ELISA) based approach. Clinical variables, including monthly headache days, peak headache pain intensity, the 6-item Headache Impact Test (HIT-6), and the Migraine Disability Assessment (MIDAS), were also addressed. The associations between the clinical variables of migraine patients and serum levels of FGF-21 and GDF-15 were studied.
RESULTS
In the multiple regression that corrected for age, we found that the serum levels of FGF-21 and GDF-15 were significantly higher in migraine sufferers than in healthy controls. A significant elevation in serum concentration of FGF-21, but not GDF-15, was observed in patients with chronic migraine (CM) compared to those with episodic migraine (EM). Regarding migraine-related disability, higher scores on the HIT-6 and MIDAS were associated with higher levels of FGF-21 and GDF-15. For the receiver operating characteristic (ROC) analysis, the diagnosis of migraine using GDF-15 showed that the area under the ROC curve (AUC) was 0.801 and the AUC of chronic migraine was 0.880.
CONCLUSION
Serum GDF-15 and FGF-21 levels are increased in patients with migraine and associated with the severity of migraine-related disability.
背景
偏头痛是一种常见疾病，具有显著的社会经济影响。偏头痛患者的代谢稳态受损，需要进一步研究。成纤维细胞生长因子 21（FGF-21）和生长分化因子 15（GDF-15）血清水平的变化是一些代谢和线粒体疾病的特征。本研究旨在评估偏头痛的存在是否会影响 FGF-21 和 GDF-15 的血清水平，并考虑代谢紊乱作为潜在的混杂因素。
方法
我们收集了 221 例偏头痛患者（153 例发作性偏头痛患者和 68 例慢性偏头痛患者）和 124 例健康对照者的血清样本。采用酶联免疫吸附试验（ELISA）方法测定 FGF-21 和 GDF-15 的血清浓度。还评估了偏头痛患者的临床变量，包括每月头痛天数、头痛峰值强度、6 项头痛影响测试（HIT-6）和偏头痛残疾评估（MIDAS）。研究了偏头痛患者的临床变量与 FGF-21 和 GDF-15 血清水平之间的关系。
结果
在校正年龄的多元回归中，我们发现偏头痛患者的 FGF-21 和 GDF-15 血清水平明显高于健康对照组。与发作性偏头痛患者相比，慢性偏头痛患者的 FGF-21 血清浓度显著升高，但 GDF-15 血清浓度无显著升高。关于偏头痛相关残疾，HIT-6 和 MIDAS 评分越高，FGF-21 和 GDF-15 的水平越高。对于接受者操作特征（ROC）分析，使用 GDF-15 诊断偏头痛的曲线下面积（AUC）为 0.801，慢性偏头痛的 AUC 为 0.880。
结论
偏头痛患者的血清 GDF-15 和 FGF-21 水平升高，与偏头痛相关残疾的严重程度相关。
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