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子宫内膜癌:分子分类与未来治疗

Endometrial cancer: molecular classification and future treatments.

作者信息

Corr Bradley, Cosgrove Casey, Spinosa Daniel, Guntupalli Saketh

机构信息

University of Colorado, Denver, CO, USA.

Ohio State University, Columbus, OH, USA.

出版信息

BMJ Med. 2022 Oct 31;1(1):e000152. doi: 10.1136/bmjmed-2022-000152. eCollection 2022.

Abstract

The treatment for endometrial cancer is rapidly evolving with the development of molecular analysis and novel strategies. Surgical resection, cytotoxic chemotherapy, endocrine or hormonal treatment, and radiation have been the staples of treatment for decades. However, precision based approaches for tumours are rapidly becoming a part of these strategies. Biomarker driven treatments are now a part of primary and recurrent treatment algorithms. This review aims to describe the current state of molecular analysis and treatment for endometrial cancer as well as to elucidate potential approaches for the near future.

摘要

随着分子分析和新策略的发展,子宫内膜癌的治疗正在迅速演变。手术切除、细胞毒性化疗、内分泌或激素治疗以及放疗几十年来一直是主要的治疗方法。然而,基于精准的肿瘤治疗方法正迅速成为这些策略的一部分。生物标志物驱动的治疗现在已成为一线治疗和复发性治疗方案的一部分。这篇综述旨在描述子宫内膜癌分子分析和治疗的现状,并阐明近期的潜在治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6481/9978763/29d2784742b9/bmjmed-2022-000152f01.jpg

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