Yamamoto Hirotsugu, Hongo Takashi, Nojima Tsuyoshi, Obara Takafumi, Kosaki Yoshinori, Ageta Kohei, Tsukahara Kohei, Yumoto Tetsuya, Nakao Atsunori, Naito Hiromichi
Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences Okayama University Okayama Japan.
Acute Med Surg. 2023 Mar 14;10(1):e828. doi: 10.1002/ams2.828. eCollection 2023 Jan-Dec.
Myxedema coma is an extremely rare but fatal endocrine emergency that requires urgent recognition and treatment. We describe a case of severe hypothermia that rapidly deteriorated to cardiac arrest that was attributed to myxedema coma.
A 52-year-old man without a history of hypothyroidism was transferred to our emergency department due to coma and profound hypothermia. The patient developed cardiac arrest immediately after hospital arrival but return of spontaneous circulation was achieved shortly after resuscitation. The patient was noted to have generalized, nonpitting edema, dry skin, severe respiratory acidosis, hyponatremia, and elevated creatinine kinase, which was indicative of hypothyroidism. Myxedema coma was confirmed by a thyroid profile. The patient was successfully treated with intravenous levothyroxine and glucocorticoid.
Although myxedema coma is a rare cause of severe hypothermia, emergency physicians should be familiar with its clinical features and management.
黏液性水肿昏迷是一种极其罕见但致命的内分泌急症,需要紧急识别和治疗。我们描述了一例严重体温过低迅速恶化为心脏骤停的病例,该病例归因于黏液性水肿昏迷。
一名无甲状腺功能减退病史的52岁男性因昏迷和深度体温过低被转至我院急诊科。患者入院后立即发生心脏骤停,但复苏后不久恢复了自主循环。患者出现全身性非凹陷性水肿、皮肤干燥、严重呼吸性酸中毒、低钠血症和肌酸激酶升高,提示甲状腺功能减退。甲状腺功能检查确诊为黏液性水肿昏迷。患者经静脉注射左甲状腺素和糖皮质激素治疗成功。
尽管黏液性水肿昏迷是严重体温过低的罕见原因,但急诊医生应熟悉其临床特征和处理方法。