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How well does a data-driven prediction method distinguish dihydrouridine from tRNA and mRNA?

作者信息

Basith Shaherin, Manavalan Balachandran

机构信息

Department of Physiology, Ajou University School of Medicine, Suwon 16499, Republic of Korea.

Department of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon 16419, Republic of Korea.

出版信息

Mol Ther Nucleic Acids. 2023 Mar 8;31:744-745. doi: 10.1016/j.omtn.2023.02.026. eCollection 2023 Mar 14.

DOI:10.1016/j.omtn.2023.02.026
PMID:36937622
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10020451/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64a2/10020451/de6eddb7b71f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64a2/10020451/de6eddb7b71f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64a2/10020451/de6eddb7b71f/gr1.jpg

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1
How well does a data-driven prediction method distinguish dihydrouridine from tRNA and mRNA?一种数据驱动的预测方法在区分二氢尿苷与转运核糖核酸和信使核糖核酸方面的效果如何?
Mol Ther Nucleic Acids. 2023 Mar 8;31:744-745. doi: 10.1016/j.omtn.2023.02.026. eCollection 2023 Mar 14.
2
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Quantitative measurement of dihydrouridine in RNA using isotope dilution liquid chromatography-mass spectrometry (LC/MS).使用同位素稀释液相色谱-质谱联用(LC/MS)对RNA中的二氢尿苷进行定量测定。
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Modified nucleosides and the chromatographic and aminoacylation behavior of tRNA(Ile) from Escherichia coli C6.修饰核苷以及来自大肠杆菌C6的异亮氨酸转运RNA(tRNA(Ile))的色谱行为和氨酰化行为
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Hydrolysis of dihydrouridine and related compounds.二氢尿苷及相关化合物的水解
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本文引用的文献

1
Self-attention enabled deep learning of dihydrouridine (D) modification on mRNAs unveiled a distinct sequence signature from tRNAs.自我注意力机制助力的深度学习揭示了信使核糖核酸(mRNA)上二氢尿嘧啶(D)修饰的独特序列特征,该特征与转运核糖核酸(tRNA)不同。
Mol Ther Nucleic Acids. 2023 Jan 27;31:411-420. doi: 10.1016/j.omtn.2023.01.014. eCollection 2023 Mar 14.
2
Applications of deep learning in understanding gene regulation.深度学习在理解基因调控中的应用。
Cell Rep Methods. 2023 Jan 11;3(1):100384. doi: 10.1016/j.crmeth.2022.100384. eCollection 2023 Jan 23.
3
Dihydrouridine in the Transcriptome: New Life for This Ancient RNA Chemical Modification.
转录组中的二氢尿嘧啶核苷:这种古老的 RNA 化学修饰的新生命。
ACS Chem Biol. 2022 Jul 15;17(7):1638-1657. doi: 10.1021/acschembio.2c00307. Epub 2022 Jun 23.
4
Transcription-wide mapping of dihydrouridine reveals that mRNA dihydrouridylation is required for meiotic chromosome segregation.转录组范围内的二氢尿嘧啶作图表明,mRNA 二氢尿嘧啶化对于减数分裂染色体分离是必需的。
Mol Cell. 2022 Jan 20;82(2):404-419.e9. doi: 10.1016/j.molcel.2021.11.003. Epub 2021 Nov 18.