• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

COVID-19患者弥漫性肺血栓的全身性低剂量阿替普酶治疗

Systemic reduced-dose alteplase for diffuse pulmonary thrombi in a COVID-19 patient.

作者信息

Colkesen Yucel

机构信息

Department of Cardiology Erdem Hospital Istanbul Turkey.

出版信息

Clin Case Rep. 2023 Mar 15;11(3):e7116. doi: 10.1002/ccr3.7116. eCollection 2023 Mar.

DOI:10.1002/ccr3.7116
PMID:36937632
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10017398/
Abstract

Pulmonary embolism has a high frequency in COVID-19 patients admitted to the intensive care unit. Low level of fibrinolysis is one of the asserted contributors to a prothrombotic state in COVID-19. Thrombotic coagulopathy is mostly encountered as diffuse pulmonary thrombi. Diffuse pulmonary microemboli was treated successfully with reduced dose thrombolysis.

摘要

在入住重症监护病房的新冠肺炎患者中，肺栓塞的发生率很高。纤维蛋白溶解水平低是新冠肺炎患者血栓前状态的公认促成因素之一。血栓性凝血病大多表现为弥漫性肺血栓。弥漫性肺微栓塞通过降低剂量的溶栓治疗获得成功。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c87/10017398/a9dc877b3c73/CCR3-11-e7116-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c87/10017398/a9dc877b3c73/CCR3-11-e7116-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c87/10017398/a9dc877b3c73/CCR3-11-e7116-g001.jpg

相似文献

1
Systemic reduced-dose alteplase for diffuse pulmonary thrombi in a COVID-19 patient.COVID-19患者弥漫性肺血栓的全身性低剂量阿替普酶治疗
Clin Case Rep. 2023 Mar 15;11(3):e7116. doi: 10.1002/ccr3.7116. eCollection 2023 Mar.
2
Successful Treatment of Refractory Massive Pulmonary Embolism with Repeated Administration of Systemic Thrombolysis.重复静脉溶栓成功治疗难治性大面积肺栓塞
Tanaffos. 2018 Feb;17(2):127-131.
3
Impact of Alteplase on Mortality in Critically Ill Patients with COVID-19 and Pulmonary Embolism.新冠肺炎合并肺栓塞危重症患者使用阿替普酶对死亡率的影响。
Viruses. 2023 Jul 7;15(7):1513. doi: 10.3390/v15071513.
4
Post-thrombolytic coagulopathy and complications in patients with pulmonary embolism treated with fixed-dose systemic alteplase.溶栓后凝血功能障碍与固定剂量全身性阿替普酶治疗肺栓塞患者的并发症。
J Thromb Thrombolysis. 2022 Nov;54(4):605-615. doi: 10.1007/s11239-022-02640-6. Epub 2022 Mar 23.
5
Treatment of Mobile Right Heart Thrombi.活动期右心血栓的治疗。
Eur J Case Rep Intern Med. 2020 Sep 17;7(12):001918. doi: 10.12890/2020_001918. eCollection 2020.
6
Analysis of cardiopulmonary findings in COVID-19 fatalities: High incidence of pulmonary artery thrombi and acute suppurative bronchopneumonia.分析 COVID-19 死亡病例的心肺发现：肺动脉血栓和急性化脓性支气管肺炎发病率高。
Cardiovasc Pathol. 2020 Nov-Dec;49:107263. doi: 10.1016/j.carpath.2020.107263. Epub 2020 Jul 16.
7
Role of Tissue Plasminogen Activator for Diffuse Pulmonary Microemboli in Coronavirus Disease 2019 Patient.组织型纤溶酶原激活物在 2019 年冠状病毒病弥漫性肺微栓塞患者中的作用。
J Cardiothorac Vasc Anesth. 2021 Jul;35(7):2137-2139. doi: 10.1053/j.jvca.2020.08.063. Epub 2020 Aug 31.
8
Half-Dose Versus Full-Dose Alteplase for Treatment of Pulmonary Embolism.半剂量与全剂量阿替普酶治疗肺栓塞的比较。
Crit Care Med. 2018 Oct;46(10):1617-1625. doi: 10.1097/CCM.0000000000003288.
9
Treatment of pulmonary embolism with argatroban and ultrasound-assisted catheter-directed thrombolysis with alteplase in a patient with heparin-induced thrombocytopenia.在一名肝素诱导的血小板减少症患者中，使用阿加曲班治疗肺栓塞并联合使用阿替普酶进行超声辅助导管定向溶栓。
Am J Health Syst Pharm. 2017 Aug 1;74(15):1153-1157. doi: 10.2146/ajhp160368.
10
COVID-19 infection complicated with acute pulmonary embolism treated with percutaneous pulmonary artery thrombectomy: a case report.经皮肺动脉血栓切除术治疗新型冠状病毒肺炎合并急性肺栓塞：一例报告
Eur Heart J Case Rep. 2022 Jun 10;6(7):ytac227. doi: 10.1093/ehjcr/ytac227. eCollection 2022 Jul.

本文引用的文献

1
The characteristics and outcomes of critically Ill patients with COVID-19 who received systemic thrombolysis for presumed pulmonary embolism: an observational study.COVID-19 重症患者接受全身溶栓治疗疑似肺栓塞的特征和结局：一项观察性研究。
J Thromb Thrombolysis. 2021 Nov;52(4):1061-1067. doi: 10.1007/s11239-021-02477-5. Epub 2021 May 8.
2
Tissue Plasminogen Activator in Critically Ill Adults with COVID-19.组织型纤溶酶原激活剂用于重症 COVID-19 成年患者
Ann Am Thorac Soc. 2021 Nov;18(11):1917-1921. doi: 10.1513/AnnalsATS.202102-127RL.
3
Coagulopathy, Venous Thromboembolism, and Anticoagulation in Patients with COVID-19.
新型冠状病毒肺炎患者的凝血病、静脉血栓栓塞和抗凝治疗。
Pharmacotherapy. 2020 Nov;40(11):1130-1151. doi: 10.1002/phar.2465. Epub 2020 Nov 3.
4
Fibrinolytic therapy for refractory COVID-19 acute respiratory distress syndrome: Scientific rationale and review.用于难治性新型冠状病毒肺炎急性呼吸窘迫综合征的纤溶治疗：科学原理与综述
Res Pract Thromb Haemost. 2020 Jun 12;4(4):524-531. doi: 10.1002/rth2.12357. eCollection 2020 May.
5
COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection.COVID-19 和凝血：SARS-CoV-2 感染的出血和血栓形成表现。
Blood. 2020 Jul 23;136(4):489-500. doi: 10.1182/blood.2020006520.
6
Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans.非裔美国人 COVID-19 患者的肺部和心脏病理学：来自新奥尔良的尸检系列。
Lancet Respir Med. 2020 Jul;8(7):681-686. doi: 10.1016/S2213-2600(20)30243-5. Epub 2020 May 27.
7
Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis.确认 COVID-19 重症 ICU 患者的血栓并发症累积发生率较高：更新分析。
Thromb Res. 2020 Jul;191:148-150. doi: 10.1016/j.thromres.2020.04.041. Epub 2020 Apr 30.
8
High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study.严重严重急性呼吸综合征冠状病毒 2 型感染患者的血栓形成风险高：一项多中心前瞻性队列研究。
Intensive Care Med. 2020 Jun;46(6):1089-1098. doi: 10.1007/s00134-020-06062-x. Epub 2020 May 4.
9
Pulmonary Embolism in Patients With COVID-19: Awareness of an Increased Prevalence.2019冠状病毒病患者的肺栓塞：对患病率增加的认识
Circulation. 2020 Jul 14;142(2):184-186. doi: 10.1161/CIRCULATIONAHA.120.047430. Epub 2020 Apr 24.
10
2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS).2019年欧洲心脏病学会（ESC）与欧洲呼吸学会（ERS）合作制定的急性肺栓塞诊断和管理指南。
Eur Heart J. 2020 Jan 21;41(4):543-603. doi: 10.1093/eurheartj/ehz405.