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免疫功能正常患者以脑梗死为首发表现的脑膜血管性神经梅毒——一例长期随访病例报告

Cerebral infarction as initial manifestation of meningovascular neurosyphilis in an immunocompetent patient - A case report with long term follow-up.

作者信息

Batinić Davor, Antulov Ronald, Klupka-Sarić Inge, Ivanković Anita, Jurina Renata, Karlović Vidaković Marijana, Talić Drlje Ivana, Arapović Jurica

机构信息

Department of Neurology University Clinical Hospital Mostar Mostar Bosnia and Herzegovina.

Faculty of Medicine University of Mostar Mostar Bosnia and Herzegovina.

出版信息

Clin Case Rep. 2023 Mar 15;11(3):e7021. doi: 10.1002/ccr3.7021. eCollection 2023 Mar.

DOI:10.1002/ccr3.7021
PMID:36937633
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10017405/
Abstract

To present a 29-year-old immunocompetent patient with neurosyphilitic changes characterized by multiple acute ischemic brain strokes along with significant narrowing of several large intracranial arteries. Ceftriaxone treatment for 14 days followed by benzathine benzylpenicillin weekly for additional 3 weeks, showed improvement in meningovascular changes.

摘要

报告一名29岁免疫功能正常的患者，其患有神经梅毒改变，特征为多发性急性缺血性脑卒中和多条大脑颅内大动脉明显狭窄。头孢曲松治疗14天，随后苄星青霉素每周一次再治疗3周，结果显示脑膜血管改变有所改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2045/10017405/a30538cd10fa/CCR3-11-e7021-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2045/10017405/31229138a034/CCR3-11-e7021-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2045/10017405/a30538cd10fa/CCR3-11-e7021-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2045/10017405/31229138a034/CCR3-11-e7021-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2045/10017405/a30538cd10fa/CCR3-11-e7021-g003.jpg

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本文引用的文献

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Neurosyphilis.神经梅毒。
Continuum (Minneap Minn). 2021 Aug 1;27(4):1018-1039. doi: 10.1212/CON.0000000000000982.
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Progressive Stroke Caused by Neurosyphilis With Concentric Enhancement in the Internal Cerebral Artery on High-Resolution Magnetic Resonance Imaging: A Case Report.高分辨率磁共振成像显示脑内动脉呈同心性强化的神经梅毒所致进展性卒中：一例报告
Front Neurol. 2021 Aug 30;12:675083. doi: 10.3389/fneur.2021.675083. eCollection 2021.
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Ischemic Stroke in Young Adults.青年缺血性脑卒中
Continuum (Minneap Minn). 2020 Apr;26(2):386-414. doi: 10.1212/CON.0000000000000833.
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Infectious Etiologies of Stroke.中风的感染性病因。
Semin Neurol. 2019 Aug;39(4):482-494. doi: 10.1055/s-0039-1687915. Epub 2019 Sep 18.
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Treatment of Syphilis-Associated Cerebral Vasculitis: Reappearance of an Old Question.梅毒相关性脑血管炎的治疗：旧问题重现。
Am J Med. 2018 Dec;131(12):1516-1519. doi: 10.1016/j.amjmed.2018.06.005. Epub 2018 Jul 2.
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2014 European guideline on the management of syphilis.2014年欧洲梅毒管理指南。
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