Suppr超能文献

转基因晚疫病抗性马铃薯会成为挪威首个获批用于商业种植的转基因作物吗?

Will genetically modified late blight resistant potatoes be the first GM crops to be approved for commercial growing in Norway?

作者信息

Forbes Edward, Wulff-Vester Anders Keim, Hvoslef-Eide Trine A K

机构信息

Department of Plant Sciences, Faculty of Biosciences, Norwegian University of Life Sciences (NMBU), Aas, Norway.

出版信息

Front Plant Sci. 2023 Mar 1;14:1137598. doi: 10.3389/fpls.2023.1137598. eCollection 2023.

Abstract

Last decade's advances in biotechnology, with the introduction of CRISPR, have challenged the regulatory framework for competent authorities all over the world. Hence, regulatory issues related to gene editing are currently high on the agenda both in the EU and in the European Economic Area (EEA) Agreement country of Norway, particularly with regards to sustainable agriculture. During the negotiations on the EEA Agreement, Norway was allowed to retain three extra aims in the Gene Technology Act: "That the production and use of GMO happens in an ethical way, is beneficial to society and is in accordance with the principle of sustainable development". We argue the case that taking sustainability into the decisions on regulating gene edited products could be easier in Norway than in the EU because of these extra aims. Late blight is our chosen example, as a devastating disease in potato that is controlled in Norway primarily by high levels of fungicide use. Also, many of these fungicides are being banned due to negative environmental and health effects. The costs of controlling late blight in Norway were calculated in 2006, and since then there have been new cultivars developed, inflation and an outbreak of war in Europe increasing farm input costs. A genetically modified (GM) cisgenic late blight resistant (LBR) potato presents a possible solution that could reduce fungicide use, but this could still be controversial. This paper aims to discuss the advantages and disadvantages of approving the commercial use of a GM LBR potato cultivar in Norway and compare these against currently used late blight management methods and conventional potato resistance breeding. We argue that a possible route for future regulatory framework could build upon the proposal by the Norwegian Biotechnology Advisory Board from 2019, also taking sustainability goals into account. This could favour a positive response from the Competent Authorities without breeching the European Economic Area (EEA) Agreement. Perhaps the EU could adopt a similar approach to fulfil their obligations towards a more sustainable agriculture?

摘要

过去十年间,随着CRISPR技术的引入,生物技术取得了诸多进展,这对全球各主管当局的监管框架构成了挑战。因此,与基因编辑相关的监管问题目前在欧盟以及挪威这个欧洲经济区(EEA)协定国的议程上占据重要位置,特别是在可持续农业方面。在关于EEA协定的谈判过程中,挪威被允许在《基因技术法》中保留三个额外目标:“转基因生物的生产和使用要符合道德规范,对社会有益,并符合可持续发展原则”。我们认为,由于这些额外目标,在挪威将可持续性纳入基因编辑产品监管决策可能比在欧盟更容易。晚疫病是我们选择的例子,它是马铃薯的一种毁灭性病害,在挪威主要通过大量使用杀菌剂来控制。此外,由于对环境和健康有负面影响,许多这类杀菌剂正被禁用。2006年计算了挪威控制晚疫病的成本,从那时起,出现了新的品种,通货膨胀以及欧洲爆发战争导致农场投入成本增加。一种转基因(GM)的顺式基因抗晚疫病(LBR)马铃薯提供了一种可能的解决方案,可以减少杀菌剂的使用,但这仍可能存在争议。本文旨在讨论在挪威批准转基因LBR马铃薯品种商业化使用的利弊,并将其与目前使用的晚疫病管理方法以及传统马铃薯抗性育种进行比较。我们认为,未来监管框架的一条可能途径可以基于挪威生物技术咨询委员会2019年的提议,并考虑可持续发展目标。这可能有利于主管当局做出积极回应,同时又不违反欧洲经济区(EEA)协定。或许欧盟可以采取类似方法来履行其在实现更可持续农业方面的义务?

相似文献

1
Will genetically modified late blight resistant potatoes be the first GM crops to be approved for commercial growing in Norway?
Front Plant Sci. 2023 Mar 1;14:1137598. doi: 10.3389/fpls.2023.1137598. eCollection 2023.
2
Is it only the regulatory status? Broadening the debate on cisgenic plants.
Environ Sci Eur. 2017;29(1):22. doi: 10.1186/s12302-017-0120-2. Epub 2017 Jun 26.
3
Late blight resistance genes in potato breeding.
Planta. 2022 May 16;255(6):127. doi: 10.1007/s00425-022-03910-6.
7
Environmental risk assessment of blight-resistant potato: use of a crop model to quantify nitrogen cycling at scales of the field and cropping system.
Environ Sci Pollut Res Int. 2017 Sep;24(26):21434-21444. doi: 10.1007/s11356-017-9769-8. Epub 2017 Jul 25.
8
Genetically modified (GM) late blight-resistant potato and consumer attitudes before and after a field visit.
GM Crops Food. 2022 Dec 31;13(1):290-298. doi: 10.1080/21645698.2022.2133396.

本文引用的文献

1
2
Global Regulation of Genetically Modified Crops Amid the Gene Edited Crop Boom - A Review.
Front Plant Sci. 2021 Feb 24;12:630396. doi: 10.3389/fpls.2021.630396. eCollection 2021.
4
Updated peer review of the pesticide risk assessment of the active substance cyazofamid.
EFSA J. 2020 Sep 4;18(9):e06232. doi: 10.2903/j.efsa.2020.6232. eCollection 2020 Sep.
6
The genetic basis of inbreeding depression in potato.
Nat Genet. 2019 Mar;51(3):374-378. doi: 10.1038/s41588-018-0319-1. Epub 2019 Jan 14.
7
Silencing of six susceptibility genes results in potato late blight resistance.
Transgenic Res. 2016 Oct;25(5):731-42. doi: 10.1007/s11248-016-9964-2. Epub 2016 May 28.
8
Accelerated cloning of a potato late blight-resistance gene using RenSeq and SMRT sequencing.
Nat Biotechnol. 2016 Jun;34(6):656-60. doi: 10.1038/nbt.3540. Epub 2016 Apr 25.
10
Broad spectrum late blight resistance in potato differential set plants MaR8 and MaR9 is conferred by multiple stacked R genes.
Theor Appl Genet. 2012 Mar;124(5):923-35. doi: 10.1007/s00122-011-1757-7. Epub 2011 Nov 23.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验