Solis-Herruzo J A, Duran A, Favela V, Castellano G, Madrid J L, Muñoz-Yagüe M T, Morillas J D, Estenoz J
Service of Gastroenterology, Hospital 1 de Octubre, School of Medicine, Universidad Complutense, Madrid, Spain.
J Hepatol. 1987 Oct;5(2):167-73. doi: 10.1016/s0168-8278(87)80569-x.
We studied the effects of unilateral lumbar sympathetic block on kidney function in eight patients with cirrhosis and hepatorenal syndrome. In five patients with basal glomerular filtration rate (GFR) below 25 ml/min, sympathetic block induced a significant increase in GFR, osmolal clearance, urinary sodium excretion, fractional excretion of filtered sodium (FENa) and effective renal plasma flow (ERPF) and a decrease in plasma renin activity. In the three patients with basal GFR greater than 25 ml/min, sympathetic block produced no significant change in renal function. We conclude that sympathetic block might improve renal function in cirrhotics with hepatorenal syndrome, particularly those with more impaired GFR.
我们研究了单侧腰交感神经阻滞对8例肝硬化合并肝肾综合征患者肾功能的影响。在5例基础肾小球滤过率（GFR）低于25ml/min的患者中，交感神经阻滞导致GFR、渗透清除率、尿钠排泄、滤过钠分数排泄（FENa）和有效肾血浆流量（ERPF）显著增加，血浆肾素活性降低。在3例基础GFR大于25ml/min的患者中，交感神经阻滞对肾功能无显著影响。我们得出结论，交感神经阻滞可能改善肝硬化合并肝肾综合征患者的肾功能，尤其是GFR受损更严重的患者。
