基于姜黄素类似物的脂质滴靶向引导的缺氧光动力疗法
Lipid droplet targeting-guided hypoxic photodynamic therapy with curcumin analogs.
作者信息
Li Xuewei, Liu Weimin, Zheng Xiuli, Jiang Meiyu, Guo Yimin, Sha Jie, Wu Jiasheng, Ren Haohui, Gao Honglei, Wang Shuai, Wang Pengfei
机构信息
Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, People's Republic of China.
School of Future Technology, University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
出版信息
Chem Commun (Camb). 2023 Apr 4;59(28):4181-4184. doi: 10.1039/d2cc07025a.
Two photosensitizers (CCOH and CCN) were designed and synthesized by introducing coumarin into the curcumin (CUR) structure. Compared with CUR, more reactive oxygen species (ROS) were generated by CCOH and CCN in type I and II synergy upon light irradiation. Cell experiments indicated that CCN with an excellent LD-targeting effect could be used to monitor the changes in the morphology and number of LDs in tumor cells during PDT.
通过将香豆素引入姜黄素（CUR）结构中，设计并合成了两种光敏剂（CCOH和CCN）。与CUR相比，CCOH和CCN在光照下通过I型和II型协同作用产生了更多的活性氧（ROS）。细胞实验表明，具有优异的溶酶体靶向作用的CCN可用于监测光动力疗法（PDT）期间肿瘤细胞中溶酶体的形态和数量变化。
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