Sturrock R R
Department of Anatomy, University of Dundee, Scotland.
J Hirnforsch. 1987;28(5):505-15.
The most prominent feature of the aged mouse neostriatum is the presence of large vacuoles. Careful inspection showed that these are vacuolated myelin sheaths and are invariably found in, or at the periphery of, the nerve fibre bundles which traverse the neostriatum. Oligodendrocytes showed little evidence of ageing but satellite oligodendrocytes contain more lipofuscin than oligodendrocytes associated with myelin sheaths. Most astrocytes contain pigment-prominent lipofuscin granules but a small minority contain numerous large pigment lipofuscin granules, and are packed with microfilaments and glycogen granules. A few astrocytes have circular nuclear inclusions filled with a fine granular material. Microglial cells contain the largest amount and variety of lipofuscin; in most cases, however, the lipofuscin is of the lipid-pigment type.
老年小鼠新纹状体最显著的特征是存在大的空泡。仔细观察发现，这些是空泡化的髓鞘，总是出现在穿过新纹状体的神经纤维束中或其周边。少突胶质细胞几乎没有衰老的迹象，但卫星少突胶质细胞比与髓鞘相关的少突胶质细胞含有更多的脂褐素。大多数星形胶质细胞含有色素——突出的脂褐素颗粒，但少数含有大量大的色素脂褐素颗粒，并且充满微丝和糖原颗粒。一些星形胶质细胞有圆形核内包涵体，充满细颗粒物质。小胶质细胞含有最多数量和种类的脂褐素；然而，在大多数情况下，脂褐素是脂质色素类型。
