五十年前：血清素与抑郁。
Fifty years on: Serotonin and depression.
机构信息
Department of Psychological Medicine, IoPPN, King's College, London, UK.
Department of Psychiatry, University of Oxford, Warneford Hospital Oxford, Oxon, UK.
出版信息
J Psychopharmacol. 2023 Mar;37(3):237-241. doi: 10.1177/02698811231161813. Epub 2023 Mar 20.
Abstract
It has been over 50 years since the original serotonin hypothesis was proposed by the British Psychiatrist Alec Coppen. Recently, some authors have questioned the validity of the hypothesis. In this narrative review, we summarise the evidence for the serotonin hypothesis of depression, focusing on psychopharmacology and molecular imaging, as well as systems-level neuroscience.
摘要
自英国精神病学家 Alec Coppen 提出最初的 5-羟色胺假说以来，已经过去了 50 多年。最近，一些作者对该假说的有效性提出了质疑。在本综述中，我们总结了抑郁症 5-羟色胺假说的证据，重点关注精神药理学和分子影像学以及系统水平的神经科学。
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