在人乳头瘤病毒阴性的头颈部鳞状细胞癌中，程序性死亡受体配体1（PD-L1）高表达与T-钙黏蛋白低表达及预后不良相关。
High PD-L1 expression associates with low T-cadherin expression and poor prognosis in human papillomavirus-negative head and neck squamous cell carcinoma.
作者信息
Wang Qiuju, Zhao Yanzhen, Chen Yan, Chen Yibo, Song Xiaoyu, Zhang Li, He Qiao, Ye Bo, Wu Lichun, Huang Xinyue, Wang Dongsheng
机构信息
Department of Clinical Laboratory, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China.
The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
出版信息
Head Neck. 2023 May;45(5):1162-1171. doi: 10.1002/hed.27329. Epub 2023 Mar 20.
BACKGROUND
This study aimed at exploring the correlation between T-cadherin and programmed death-ligand 1 (PD-L1), as well as their prognostic value in patients with human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC).
METHODS
Immunohistochemical staining was used to identify the protein expression of T-cadherin and PD-L1. Spearman linear correlation analysis was used to determine their association. Kaplan-Meier analysis was utilized to plot overall survival (OS) and disease-free survival (DFS) curves. Cox proportional hazards regression was used to conduct univariate and multivariate analysis.
RESULTS
The results showed a negative association between protein expression of T-cadherin and PD-L1 (r = -0.760, p < 0.001), positive expression of T-cadherin was associated with a better OS (p < 0.001) and DFS (p < 0.001), while positive PD-L1 expression was associated with a worse OS (p = 0.002) and DFS (p < 0.001). The expression of T-cadherin and PD-L1 were independent prognostic predictors for OS and DFS.
CONCLUSIONS
In conclusion, expression of T-cadherin and PD-L1 were largely inversely correlated and independent prognostic factors for patients with HPV-negative HNSCC.
背景
本研究旨在探讨T-钙黏蛋白与程序性死亡配体1（PD-L1）之间的相关性，以及它们在人乳头瘤病毒（HPV）阴性的头颈部鳞状细胞癌（HNSCC）患者中的预后价值。
方法
采用免疫组织化学染色法鉴定T-钙黏蛋白和PD-L1的蛋白表达。采用Spearman线性相关分析确定它们之间的关联。利用Kaplan-Meier分析绘制总生存期（OS）和无病生存期（DFS）曲线。采用Cox比例风险回归进行单因素和多因素分析。
结果
结果显示T-钙黏蛋白和PD-L1的蛋白表达呈负相关（r = -0.760，p < 0.001），T-钙黏蛋白阳性表达与较好的OS（p < 0.001）和DFS（p < 0.001）相关，而PD-L1阳性表达与较差的OS（p = 0.002）和DFS（p < 0.001）相关。T-钙黏蛋白和PD-L1的表达是OS和DFS的独立预后预测指标。
结论
总之，T-钙黏蛋白和PD-L1的表达在很大程度上呈负相关，并且是HPV阴性HNSCC患者的独立预后因素。
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