Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
Department of Otolaryngology-Head and Neck Surgery, University of Virginia, Charlottesville, Virginia, USA.
Otolaryngol Head Neck Surg. 2023 Jun;168(6):1346-1352. doi: 10.1002/ohn.224. Epub 2023 Jan 29.
To compare outcomes of facial nerve repair or grafting following facial nerve-sacrificing procedures among patients treated with and without postoperative radiotherapy (RT).
PubMed, OVID, Conference Papers Index, Cochrane Library, ClinicalTrials.gov.
Databases were searched using terms including "facial nerve," "graft," "repair," and "radiotherapy." Abstracts mentioning facial nerve repair and evaluation of facial nerve function were included for full-text review. Studies that utilized the House-Brackmann or similar validated scale for evaluation of postoperative facial nerve function were selected for review. All identified studies were included in a pooled t test analysis.
Twelve studies with 142 patients were included in the systematic review. All 12 studies individually demonstrated no significant difference in facial nerve outcomes between patients who received postoperative radiation and patients who did not. A pooled t test of data from all studies also demonstrated no significant difference in postoperative facial nerve function between the postoperative RT and non-RT groups (t stat = 0.92, p = .36).
This analysis, including 12 studies, demonstrated that among patients undergoing facial nerve grafting or repair, there was no significant difference in postoperative facial nerve function between postoperative RT and non-RT patients. Due to the small sample size and variability in study methods, further studies directly comparing outcomes between patients with and without postoperative RT would be beneficial.
比较接受和不接受术后放疗（RT）的面神经牺牲性手术患者面神经修复或移植后的结局。
PubMed、OVID、会议论文索引、考科蓝图书馆、ClinicalTrials.gov。
使用“面神经”、“移植”、“修复”和“放疗”等术语在数据库中进行检索。包括提及面神经修复和评估面神经功能的摘要均进行全文审查。选择使用 House-Brackmann 或类似的经验证的量表评估术后面神经功能的研究进行综述。所有确定的研究均纳入汇总 t 检验分析。
系统评价纳入了 12 项研究共 142 例患者。所有 12 项研究均单独表明，接受术后放疗和未接受放疗的患者之间面神经结局无显著差异。对所有研究数据进行的汇总 t 检验也表明，术后 RT 组和非 RT 组之间术后面神经功能无显著差异（t 统计 = 0.92，p = .36）。
这项包括 12 项研究的分析表明，在行面神经移植或修复的患者中，术后 RT 与非 RT 患者之间的术后面神经功能无显著差异。由于样本量小和研究方法的变异性，比较接受和不接受术后 RT 患者的结局的进一步研究将是有益的。
