Department of Otolaryngology and Head-Neck Surgery, Mayo Clinic Jacksonville, Jacksonville, Florida, USA.
Ohio University Heritage College of Osteopathic Medicine, Athens, Ohio, USA.
Otolaryngol Head Neck Surg. 2023 Jul;169(1):12-20. doi: 10.1002/ohn.248. Epub 2023 Jan 29.
Previous studies have suggested that patients with aspirin-exacerbated respiratory disease (AERD) have a high likelihood of alcohol intolerance. The purpose of this systematic review is to identify if there is sufficient evidence to confirm this correlation and the impact of medical therapy on subsequent alcohol tolerance.
PubMed, EMBASE, SCOPUS, EBSCO, Google Scholar, Cochrane Library, and Grey literature. We also performed snowballing on the identified observational studies (OS) for additional data.
A systematic review was conducted from 1968 to 2022 to identify those studies describing AERD symptomatology triggered by alcohol intake. The primary outcome was to analyze the current literature for the association between alcohol intolerance and AERD symptoms. The secondary outcome looked for improvement in alcohol tolerance after aspirin desensitization or biological therapy.
A total of 775 studies were identified and 40 abstracts were evaluated. From these, 5 studies met the inclusion criteria. Of the 5 manuscripts, there was 1 case-control, 2 cohort, and 2 cross-sectional studies. A total of 522 participants with AERD and a history of alcohol consumption were included, with 52.8% reporting at least 1 sinopulmonary exacerbation after alcohol intake. One of 3 studies noted improvement in alcohol tolerance after medical therapy with aspirin desensitization.
The current literature suggests that patients with AERD have a high risk of alcohol intolerance. Additionally, aspirin desensitization may improve alcohol tolerance in this patient population.
先前的研究表明，阿司匹林加重的呼吸道疾病（AERD）患者极有可能对酒精不耐受。本系统评价的目的是确定是否有足够的证据来证实这种相关性以及医学治疗对随后的酒精耐受性的影响。
PubMed、EMBASE、SCOPUS、EBSCO、Google Scholar、Cochrane 图书馆和灰色文献。我们还对已确定的观察性研究（OS）进行了滚雪球式搜索，以获取更多数据。
从 1968 年到 2022 年进行了一项系统评价，以确定那些描述由酒精摄入引发的 AERD 症状的研究。主要结果是分析当前文献中酒精不耐受与 AERD 症状之间的关联。次要结果是寻找阿司匹林脱敏或生物治疗后酒精耐受性的改善。
共确定了 775 项研究，并评估了 40 份摘要。其中 5 项研究符合纳入标准。在这 5 篇论文中，有 1 项病例对照研究、2 项队列研究和 2 项横断面研究。共纳入 522 名有 AERD 病史且有饮酒史的患者，其中 52.8%的患者报告饮酒后至少有 1 次鼻肺恶化。有 3 项研究中的 1 项指出，阿司匹林脱敏治疗后，酒精耐受性有所改善。
目前的文献表明，AERD 患者对酒精不耐受的风险较高。此外，阿司匹林脱敏治疗可能会改善该患者群体的酒精耐受性。
