Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Department of Otolaryngology, Taichung Veterans General Hospital, Taichung, Taiwan.
Otolaryngol Head Neck Surg. 2023 Jun;168(6):1545-1550. doi: 10.1002/ohn.237. Epub 2023 Jan 27.
To compare culture results between eosinophilic chronic rhinosinusitis (CRS) with nasal polyps (ECRSwNP) and noneosinophilic CRS with nasal polyps (nECRSwNP).
Retrospective study.
Tertiary medical center.
We retrospectively analyzed a cohort of CRSwNP patients undergoing primary functional endoscopic sinus surgery. Prior to surgery, swab samples for bacterial culture were collected from their middle meatus using cotton tips. After surgery, postoperative specimens were histologically examined for tissue eosinophilia. A tissue eosinophil density of >10 cells at high power magnification was used to discriminate between ECRSwNP and nECRSwNP.
A total of 295 patients were studied with polyps present on 471 sides of the nasal cavity. Among them, 236 sides were ECRSwNP, and the remaining 235 sides were nECRSwNP. Bacterial growth was found in 94 ECRSwNP sides, and in 88 nECRSwNP sides. Culture rates were similar between ECRSwNP and nECRSwNP sides (p = .595). However, Gram-negative aerobes were found in 25 of 236 ECRSwNP sides, and in 42 of 235 nECRSwNP sides. The Gram-negative culture rate was significantly higher in nECRSwNP than in ECRSwNP sides (p = .024).
The bacteriology of CRS was different between ECRSwNP and nECRSwNP. The Gram-negative aerobes were present more in nECRSwNP than in ECRSwNP.
比较伴有嗜酸性粒细胞的慢性鼻-鼻窦炎伴鼻息肉（ECRSwNP）与不伴嗜酸性粒细胞的慢性鼻-鼻窦炎伴鼻息肉（nECRSwNP）的培养结果。
回顾性研究。
三级医疗中心。
我们回顾性分析了一组接受初次功能性内镜鼻窦手术的 CRSwNP 患者的队列。在手术前，使用棉签从中鼻道采集细菌培养拭子样本。手术后，对术后标本进行组织嗜酸性粒细胞检查。高倍镜下组织嗜酸性粒细胞密度>10 个细胞用于区分 ECRSwNP 和 nECRSwNP。
共对 295 例患者进行了研究，其中 471 侧鼻腔存在息肉。其中，236 侧为 ECRSwNP，其余 235 侧为 nECRSwNP。94 侧 ECRSwNP 和 88 侧 nECRSwNP 发现细菌生长。ECRSwNP 和 nECRSwNP 侧的培养率相似（p = .595）。然而，236 侧 ECRSwNP 中有 25 侧发现革兰阴性需氧菌，而 235 侧 nECRSwNP 中有 42 侧发现革兰阴性需氧菌。nECRSwNP 中革兰阴性培养率明显高于 ECRSwNP（p = .024）。
ECRSwNP 和 nECRSwNP 的鼻-鼻窦炎细菌学不同。nECRSwNP 中革兰阴性需氧菌的存在多于 ECRSwNP。
