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肟@锆基金属有机框架杂化材料作为一种潜在的有机磷中毒解毒剂。

Oxime@Zirconium-Metal-Organic Framework Hybrid Material as a Potential Antidote for Organophosphate Poisoning.

机构信息

Departamento de Química Inorgánica, Universidad de Granada, Avenida Fuentenueva S/N, Granada 18071, Spain.

出版信息

Inorg Chem. 2023 Apr 3;62(13):5049-5053. doi: 10.1021/acs.inorgchem.3c00121. Epub 2023 Mar 20.

DOI:10.1021/acs.inorgchem.3c00121
PMID:36939843
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10074384/
Abstract

A novel material with dual activity toward organophosphate (OP) poisoning, based on Zr-MOF-808 and neutral oxime RS69N, has been prepared. The hybrid material has a significant drug payload (5.2 ± 0.9 oxime to MOF-808 molar ratio) and shows a sustained oxime release in simulated physiological media, leading to the successful reactivation of OP-inhibited acetylcholinesterase. At the same time, the hybrid system presents an efficient and moderately fast removal rate of a toxic organophosphorus model compound (diisopropylfluorophosphate) from simulated physiological media ( = 183 min; 95% removal rate after 24 h).

摘要

一种基于 Zr-MOF-808 和中性肟 RS69N 的新型双重活性有机磷（OP）中毒治疗材料已经被制备出来。该复合材料具有较高的药物负载量（MOF-808 与肟的摩尔比为 5.2 ± 0.9），并在模拟生理介质中表现出持续的肟释放，从而成功地使被 OP 抑制的乙酰胆碱酯酶重新活化。同时，该混合体系对模拟生理介质中的有毒有机磷模型化合物（二异丙基氟膦酸酯）具有高效且适中的快速去除率（ = 183 min；24 h 后去除率达到 95%）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac5c/10074384/d3f2009cc84e/ic3c00121_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac5c/10074384/f32213a83a8a/ic3c00121_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac5c/10074384/905076af66d3/ic3c00121_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac5c/10074384/250e857a1d70/ic3c00121_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac5c/10074384/d3f2009cc84e/ic3c00121_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac5c/10074384/f32213a83a8a/ic3c00121_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac5c/10074384/905076af66d3/ic3c00121_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac5c/10074384/250e857a1d70/ic3c00121_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac5c/10074384/d3f2009cc84e/ic3c00121_0003.jpg

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