异土木香内酯的药理作用研究进展。

Research progress on pharmacological effects of isoalantolactone.

机构信息

School of Basic Medical Science, Hebei University, Baoding, Hebei, P. R. China.

College of Traditional Chinese Medicine, Hebei University, Baoding, Hebei, P. R. China.

出版信息

J Pharm Pharmacol. 2023 Apr 17;75(5):585-592. doi: 10.1093/jpp/rgac103.

DOI:10.1093/jpp/rgac103

PMID:36940405

Abstract

OBJECTIVES

To review the pharmacokinetics, pharmacological action and mechanism of isoalantolactone (IAL). Explore the therapeutic potential of isoalantolactone.Keywords including isoalantolactone, pharmacological effects, pharmacokinetic and toxicity were used for literature search in PubMed, Excerpta Medica Database (EMBASE) and Web of Science, to identify articles published from 1992 to 2022.

KEY FINDINGS

IAL has a great many obiological activities such as anti-inflammatory, antioxidant, antitumour, neuroprotection, with no obvious toxicity. This review suggests that IAL exerts different pharmacological effects with different mechanisms of action at different doses, and may be a potential drug candidate to treat inflammatory diseases, neurodegenerative diseases and cancer, with medicinal value.

SUMMARY

IAL has various pharmacological activities and medicinal values. However, further research is needed to determine its specific intracellular action sites and targets, so as to fully understand its therapeutic mechanism and provide a reference for the treatment of related diseases.

摘要

目的

综述土木香内酯（IAL）的药代动力学、药理作用及作用机制。探讨土木香内酯的治疗潜力。关键词包括土木香内酯、药理作用、药代动力学和毒性，在 PubMed、Excerpta Medica Database（EMBASE）和 Web of Science 中进行文献检索，以确定 1992 年至 2022 年发表的文章。