• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Evolving insights into the pleiotropic cardioprotective mechanisms of SGLT2 inhibitors.对钠-葡萄糖协同转运蛋白2抑制剂多效性心脏保护机制的认识不断深入。
Naunyn Schmiedebergs Arch Pharmacol. 2023 Apr;396(4):589-592. doi: 10.1007/s00210-023-02459-9.
2
Diabetes mellitus: Cardiovascular and renal benefits of SGLT2 inhibition: insights from CANVAS.糖尿病：钠-葡萄糖协同转运蛋白2抑制剂对心血管和肾脏的益处：来自CANVAS研究的见解
Nat Rev Nephrol. 2017 Sep;13(9):517-518. doi: 10.1038/nrneph.2017.113. Epub 2017 Aug 7.
3
SGLT2 Inhibitors and Cardiovascular Outcomes: Do they Differ or there is a Class Effect? New Insights from the EMPA-REG OUTCOME trial and the CVD-REAL Study.钠-葡萄糖共转运蛋白 2 抑制剂与心血管结局：它们有差异还是存在类效应？来自 EMPA-REG OUTCOME 试验和 CVD-REAL 研究的新见解。
Curr Cardiol Rev. 2020;16(4):258-265. doi: 10.2174/1573403X15666190730094215.
4
Editorial to the Special Issue on Sglt2 Inhibitors Vol. 1.关于 Sglt2 抑制剂特刊的社论 第 1 卷。
Int J Mol Sci. 2023 Apr 7;24(8):6873. doi: 10.3390/ijms24086873.
5
The growing clinical effect of SGLT2 inhibitors.钠-葡萄糖协同转运蛋白2抑制剂日益增强的临床疗效。
Lancet Diabetes Endocrinol. 2023 Apr;11(4):218-219. doi: 10.1016/S2213-8587(23)00065-7. Epub 2023 Mar 3.
6
Alleviation of functional iron deficiency by SGLT2 inhibition in patients with type 2 diabetes.2型糖尿病患者中，钠-葡萄糖协同转运蛋白2抑制剂缓解功能性缺铁。
Diabetes Obes Metab. 2023 May;25(5):1143-1146. doi: 10.1111/dom.14963. Epub 2023 Jan 17.
7
Editorial for the Special Issue on Sglt2 Inhibitors (Volume 2).关于 Sglt2 抑制剂的特刊社论（第 2 卷）。
Int J Mol Sci. 2023 Nov 28;24(23):16865. doi: 10.3390/ijms242316865.
8
Should We Be Combining GLP-1 Receptor Agonists and SGLT2 Inhibitors in Treating Diabetes?在治疗糖尿病时，我们应该联合使用GLP-1受体激动剂和SGLT2抑制剂吗？
Am J Med. 2018 May;131(5):461-463. doi: 10.1016/j.amjmed.2017.11.052. Epub 2018 Jan 5.
9
Mechanisms of Protective Effects of SGLT2 Inhibitors in Cardiovascular Disease and Renal Dysfunction.SGLT2 抑制剂在心血管疾病和肾功能障碍中的保护作用机制。
Curr Top Med Chem. 2019;19(20):1818-1849. doi: 10.2174/1568026619666190828161409.
10
How Sweet It Is: A Perspective on the Potential Anti-Tumor Role for SGLT2 Inhibitors.如此美妙：对SGLT2抑制剂潜在抗肿瘤作用的见解
Kidney360. 2023 Sep 1;4(9):e1322-e1324. doi: 10.34067/KID.0000000000000219.

引用本文的文献

1
The alleviative effects of canagliflozin on imiquimod-induced mouse model of psoriasis-like inflammation.卡格列净对咪喹莫特诱导的银屑病样炎症小鼠模型的缓解作用。
Naunyn Schmiedebergs Arch Pharmacol. 2025 Mar;398(3):2695-2715. doi: 10.1007/s00210-024-03406-y. Epub 2024 Sep 10.

本文引用的文献

1
Raddeanin A promotes autophagy-induced apoptosis by inactivating PI3K/AKT/mTOR pathway in lung adenocarcinoma cells.冬凌草甲素通过抑制 PI3K/AKT/mTOR 通路促进肺腺癌细胞自噬性凋亡。
Naunyn Schmiedebergs Arch Pharmacol. 2023 Sep;396(9):1987-1997. doi: 10.1007/s00210-023-02447-z. Epub 2023 Mar 8.
2
Empagliflozin inhibits excessive autophagy through the AMPK/GSK3β signalling pathway in diabetic cardiomyopathy.恩格列净通过 AMPK/GSK3β 信号通路抑制糖尿病心肌病中的过度自噬。
Cardiovasc Res. 2023 May 22;119(5):1175-1189. doi: 10.1093/cvr/cvad009.
3
Critical Reanalysis of the Mechanisms Underlying the Cardiorenal Benefits of SGLT2 Inhibitors and Reaffirmation of the Nutrient Deprivation Signaling/Autophagy Hypothesis.对 SGLT2 抑制剂心脏肾脏获益机制的关键再分析及营养剥夺信号/自噬假说的再确认。
Circulation. 2022 Nov;146(18):1383-1405. doi: 10.1161/CIRCULATIONAHA.122.061732. Epub 2022 Oct 31.
4
Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology.心房肌细胞中的炎症信号转导：心房颤动病理生理学中的一个新的统一原则。
Nat Rev Cardiol. 2023 Mar;20(3):145-167. doi: 10.1038/s41569-022-00759-w. Epub 2022 Sep 15.
5
Dapagliflozin Alleviates Coxsackievirus B3-induced Acute Viral Myocarditis by Regulating the Macrophage Polarization Through Stat3-related Pathways.达格列净通过 Stat3 相关通路调控巨噬细胞极化缓解柯萨奇 B3 病毒诱导的急性病毒性心肌炎。
Inflammation. 2022 Oct;45(5):2078-2090. doi: 10.1007/s10753-022-01677-2. Epub 2022 Jun 8.
6
Empagliflozin alleviates myocardial I/R injury and cardiomyocyte apoptosis via inhibiting ER stress-induced autophagy and the PERK/ATF4/Beclin1 pathway.恩格列净通过抑制内质网应激诱导的自噬和 PERK/ATF4/Beclin1 通路减轻心肌缺血再灌注损伤和心肌细胞凋亡。
J Drug Target. 2022 Sep;30(8):858-872. doi: 10.1080/1061186X.2022.2064479. Epub 2022 May 12.
7
2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.2022年美国心脏协会/美国心脏病学会/美国心力衰竭学会心力衰竭管理指南：执行摘要：美国心脏病学会/美国心脏协会临床实践指南联合委员会报告
Circulation. 2022 May 3;145(18):e876-e894. doi: 10.1161/CIR.0000000000001062. Epub 2022 Apr 1.
8
Direct cardiac effects of SGLT2 inhibitors.钠-葡萄糖协同转运蛋白 2 抑制剂的心脏直接作用。
Cardiovasc Diabetol. 2022 Mar 18;21(1):45. doi: 10.1186/s12933-022-01480-1.
9
Sodium-Glucose Co-transporter-2 Inhibitor of Dapagliflozin Attenuates Myocardial Ischemia/Reperfusion Injury by Limiting NLRP3 Inflammasome Activation and Modulating Autophagy.达格列净的钠-葡萄糖协同转运蛋白2抑制剂通过限制NLRP3炎性小体激活和调节自噬减轻心肌缺血/再灌注损伤。
Front Cardiovasc Med. 2022 Jan 10;8:768214. doi: 10.3389/fcvm.2021.768214. eCollection 2021.
10
Association of SGLT2 Inhibitors With Risk of Atrial Fibrillation and Stroke in Patients With and Without Type 2 Diabetes: A Systemic Review and Meta-Analysis of Randomized Controlled Trials.SGLT2 抑制剂与伴有和不伴有 2 型糖尿病患者的房颤和卒中风险的关联：一项随机对照试验的系统评价和荟萃分析。
J Cardiovasc Pharmacol. 2022 Feb 1;79(2):e145-e152. doi: 10.1097/FJC.0000000000001183.

Evolving insights into the pleiotropic cardioprotective mechanisms of SGLT2 inhibitors.

作者信息

Fender Anke C, Dobrev Dobromir

机构信息

Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Hufelandstrasse 55, 45147, Essen, Germany.

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 2023 Apr;396(4):589-592. doi: 10.1007/s00210-023-02459-9.

DOI:10.1007/s00210-023-02459-9
PMID:36943455
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10042952/
Abstract
摘要