Chockalingam U, Murphy E, Ophoven J C, Georgieff M K
Department of Pediatrics, University of Minnesota Hospital, Minneapolis.
J Pediatr Gastroenterol Nutr. 1987 Mar-Apr;6(2):276-80. doi: 10.1097/00005176-198703000-00020.
Serum transferrin levels assess protein status in older children and adults. To generate standards for its use in newborn infants, we measured umbilical cord serum transferrin levels in 161 appropriate (AGA), 25 large (LGA) and 16 small (SGA) for gestational age infants between 25 and 43 weeks' gestation. We also assessed the effects of intrauterine growth, exposure to prenatal steroids, and presence of pulmonary maturity on neonatal transferrin levels. Cord transferrin levels in AGA infants were significantly correlated with increasing gestational age (r = 0.60; p less than 0.001). Infants born before 37 weeks' gestation had significantly lower transferrin levels, when compared with those born at term (p less than 0.001). LGA infants had significantly higher levels than age-matched AGA infants (253 +/- 75 vs. 214 +/- 53 mg/dl; p less than 0.025). Despite significantly lower mean birth weights (p less than 0.001), SGA infants also had significantly higher levels than gestational age-matched AGA controls (227 +/- 63 vs. 167 +/- 40 mg/dl; p less than 0.005). For infants less than 35 weeks' gestation, neither the 20 preterm infants with exposure to prenatal steroids (maternal betamethasone), nor the 26 infants with pulmonary maturity had significantly elevated transferrin levels, when compared with gestational age-matched control infants. Newborn transferrin levels correlate well with gestational age and are significantly affected by size for dates, but not by a brief course of prenatal steroids or by pulmonary maturity.
血清转铁蛋白水平可评估大龄儿童和成人的蛋白质状况。为制定其在新生儿中应用的标准，我们测量了161例孕龄在25至43周之间的适于胎龄（AGA）、25例大于胎龄（LGA）和16例小于胎龄（SGA）婴儿的脐血血清转铁蛋白水平。我们还评估了宫内生长、产前类固醇暴露及肺成熟度对新生儿转铁蛋白水平的影响。AGA婴儿的脐带转铁蛋白水平与孕龄增加显著相关（r = 0.60；p小于0.001）。与足月出生的婴儿相比，孕37周前出生的婴儿转铁蛋白水平显著较低（p小于0.001）。LGA婴儿的水平显著高于年龄匹配的AGA婴儿（253±75 vs. 214±53 mg/dl；p小于0.025）。尽管平均出生体重显著较低（p小于0.001），SGA婴儿的转铁蛋白水平也显著高于孕龄匹配的AGA对照婴儿（227±63 vs. 167±40 mg/dl；p小于0.005）。对于孕龄小于35周的婴儿，与孕龄匹配的对照婴儿相比，20例暴露于产前类固醇（母亲使用倍他米松）的早产儿和26例肺成熟的婴儿转铁蛋白水平均未显著升高。新生儿转铁蛋白水平与孕龄密切相关，且受出生体重影响显著，但不受短期产前类固醇治疗或肺成熟度的影响。
