母细胞性浆细胞样树突状细胞肿瘤
Blastic Plasmacytoid Dendritic Cell Neoplasm
作者信息
Singh Annapoorna, Saab Chalhoub Mario W., Singh Daulath
机构信息
Kansas City School of Medicine
Medical College of Wisconsin
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, clinically aggressive hematologic malignancy characterized by cutaneous lesions, bone marrow involvement, and leukemic dissemination. Blastic plasmacytoid dendritic cell neoplasm terminology and the underlying pathophysiology process have evolved over decades. It was previously known as acute agranular CD4+ natural killer (NK) cell leukemia in 1995. After it was discovered that the cell of origin is the plasmacytoid dendritic cell in 2008, the World Health Organization (WHO) coined the term blastic plasmacytoid dendritic cell neoplasm to classify hematological malignancies.
母细胞性浆细胞样树突状细胞肿瘤（BPDCN）是一种罕见的、临床侵袭性血液系统恶性肿瘤，其特征为皮肤病变、骨髓受累和白血病播散。母细胞性浆细胞样树突状细胞肿瘤的术语及其潜在的病理生理过程在过去几十年中不断演变。1995年它曾被称为急性无颗粒CD4+自然杀伤（NK）细胞白血病。2008年发现其起源细胞是浆细胞样树突状细胞后，世界卫生组织（WHO）创造了母细胞性浆细胞样树突状细胞肿瘤这一术语来对血液系统恶性肿瘤进行分类。
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