Ophthalmic Surg Lasers Imaging Retina. 2023 Mar;54(3):131-138. doi: 10.3928/23258160-20230221-04. Epub 2023 Mar 1.
[Box: see text] Background and Objective: This meta-analysis evaluates treat-and-extend regimens relative to monthly and as-needed (prn) regimens using anti-vascular endothelial growth factor agents for diabetic macular edema and macular edema secondary to retinal vein occlusion.
Comparative studies evaluating a treat-and-extend regimen relative to a monthly or prn regimen with anti-vascular endothelial growth factor therapy for diabetic macular edema or macular edema secondary to retinal vein occlusion were included following a systematic literature search.
Seven studies of 984 eyes were included. Relative to a monthly regimen, treat-and-extend was similar for change in best-corrected visual acuity at final follow-up ( = .59) and had a lower number of injections ( < .00001). Relative to a prn regimen, treat-and-extend was similar for change in best-corrected visual acuity at final follow-up ( = .84) and was associated with a higher number of injections ( = .02).
This meta-analysis found that a treat-and extend regimen was nonsignificantly different compared to monthly and prn regimens in efficacy and safety end points. .
本荟萃分析评估了抗血管内皮生长因子药物治疗糖尿病性黄斑水肿和视网膜静脉阻塞所致黄斑水肿时，与每月治疗和按需（prn）治疗方案相比，治疗和延伸方案的疗效。
通过系统文献检索，纳入了评估抗血管内皮生长因子治疗糖尿病性黄斑水肿或视网膜静脉阻塞所致黄斑水肿时，治疗和延伸方案与每月或 prn 方案相比的比较研究。
纳入了 7 项涉及 984 只眼的研究。与每月治疗方案相比，治疗和延伸方案在最终随访时最佳矫正视力的变化方面相似（ =.59），且注射次数较少（ <.00001）。与 prn 方案相比，治疗和延伸方案在最终随访时最佳矫正视力的变化方面相似（ =.84），但注射次数较多（ =.02）。
本荟萃分析发现，与每月和 prn 方案相比，治疗和延伸方案在疗效和安全性终点方面无显著差异。
