Zhu J B, Koizumi T
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
J Pharmacobiodyn. 1987 Aug;10(8):377-83. doi: 10.1248/bpb1978.10.377.
Experiments concerning the diuretic effect and disposition of furosemide were performed in nine healthy male volunteers. During the test period, each of subject was given 50 ml of water every half an hour. Under this experimental condition, interesting phenomena, such as almost identical duration of diuretic effect independent of given dose and the so-called clockwise hysteresis of the concentration-effect curve were observed. These phenomena revealed that the body water regulation system had intervened in the pharmacodynamics of furosemide. Based on experimental results, a model and a new equation are presented, which describe the quantitative relationship of the drug disposition, the diuretic response and the body water regulatory function.
在9名健康男性志愿者身上进行了有关呋塞米利尿作用及处置情况的实验。在测试期间，每隔半小时给每位受试者50毫升水。在这种实验条件下，观察到了一些有趣的现象，比如利尿作用持续时间几乎与给药剂量无关，以及浓度-效应曲线出现所谓的顺时针滞后现象。这些现象表明，人体水调节系统对呋塞米的药效学产生了干预。基于实验结果，提出了一个模型和一个新方程，用以描述药物处置、利尿反应和人体水调节功能之间的定量关系。
