School of Health Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
Child Psychiatry Hum Dev. 2024 Dec;55(6):1655-1663. doi: 10.1007/s10578-023-01514-z. Epub 2023 Mar 22.
This study presents an overview of prescribing patterns and provides insight into the current management practice for the core symptoms and comorbidities of ASD in children. A quantitative retrospective study was conducted at a public hospital in KwaZulu-Natal, South Africa by reviewing patient files of children diagnosed with ASD and meeting the inclusion criteria for the study. A descriptive analysis of data was done to identify treatment trends and patient therapeutic outcomes. A total of 181 children met the inclusion criteria of the study. Risperidone was the most frequently prescribed drug (88%) for the management of comorbidities and/or core symptoms of ASD. Drugs prescribed to manage ASD comorbidities included methylphenidate, melatonin, sodium valproate, risperidone, oxybutynin, carbamazepine, and others. Except for risperidone, there were no additional drugs that targeted the core symptoms of ASD. Non-pharmacological therapies were often used collaboratively with medication to manage ASD symptoms. In 41% of patients, there were improvements in their symptoms.
这项研究概述了处方模式，并深入了解了目前儿童自闭症核心症状和合并症的管理实践。在南非夸祖鲁-纳塔尔省的一家公立医院，通过审查符合研究纳入标准的自闭症儿童的患者档案，进行了一项定量回顾性研究。对数据进行描述性分析，以确定治疗趋势和患者治疗结果。共有 181 名儿童符合研究纳入标准。利培酮是最常开的药物（88%），用于治疗自闭症的合并症和/或核心症状。用于治疗自闭症合并症的药物包括哌醋甲酯、褪黑素、丙戊酸钠、利培酮、奥昔布宁、卡马西平等。除了利培酮，没有其他针对自闭症核心症状的药物。非药物疗法通常与药物联合使用来治疗自闭症症状。在 41%的患者中，他们的症状有所改善。
