Ha Tae Sun, Cho Gyu Seok, Shin Eung Jin, Ryu Seung Wan, Ryu Keun Won, Kim Min Chan, Hyung Woo Jin, Kim Chan Young, Lee Hyuk-Joon, Shin Dong Woo, Lee Jun Ho
Department of Surgery, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
Department of Surgery, Keimyung University School of Medicine, Daegu, Korea.
Korean J Clin Oncol. 2022 Jun;18(1):36-46. doi: 10.14216/kjco.22005. Epub 2022 Jun 30.
The present study was performed to investigate the effects of local complications (LC) on long-term survival and cancer recurrence in patients undergoing curative gastrectomy for gastric cancer.
We analyzed 2,627 patients after curative gastrectomy for gastric cancer between January 2001 and December 2006. Patients were classified into groups no complications (NC), LC, or systemic complications (SC).
Among the 2,627 patients, 475 patients developed complications (LC group [n=374, 14.2%] and SC group [n=101, 3.9%]). The 5-year cancer-specific survival rate was significantly poorer in the LC group compared to the NC and SC groups (LC, 78.0%; NC, 85.4%; SC, 80.2%; P=0.007). The occurrence of LC was identified as a significant independent prognostic factor for overall and cancer-specific survival (hazard ratio [HR], 2.08; 95% confidence interval [CI], 1.46-2.97; P=0.001 and HR, 1.77; 95% CI, 1.12-2.81; P=0.015). The tumor recurrence rates were higher in the LC group than the in other two groups (LC, 23.5%; NC, 15.4%; SC, 15.8%; P<0.001). The occurrence of LC was an independent predictor of tumor recurrence in patients undergoing curative gastrectomy for gastric cancer (HR, 1.55; 95% CI, 1.11-2.17; P=0.011).
LC are associated with adverse long-term outcomes in patients after curative gastrectomy for advanced gastric cancer.
本研究旨在探讨局部并发症（LC）对接受胃癌根治性胃切除术患者长期生存及癌症复发的影响。
我们分析了2001年1月至2006年12月期间接受胃癌根治性胃切除术的2627例患者。患者被分为无并发症组（NC）、局部并发症组（LC）或全身并发症组（SC）。
在2627例患者中，475例发生了并发症（LC组[n = 374，14.2%]和SC组[n = 上一页 101，3.9%]）。与NC组和SC组相比，LC组的5年癌症特异性生存率显著更低（LC组为78.0%；NC组为85.4%；SC组为80.2%；P = 0.007）。LC的发生被确定为总体生存和癌症特异性生存的显著独立预后因素（风险比[HR]为2.08；95%置信区间[CI]为1.46 - 2.97；P = 0.001，HR为1.77；95%CI为1.12 - 2.81；P = 0.015）。LC组的肿瘤复发率高于其他两组（LC组为23.5%；NC组为15.4%；SC组为15.8%；P < 0.001）。LC的发生是接受胃癌根治性胃切除术患者肿瘤复发的独立预测因素（HR为1.55；95%CI为1.11 - 2.17；P = 0.011）。
局部并发症与进展期胃癌根治性胃切除术后患者的不良长期预后相关。
