Ortega-Cruz Diana, Eugenio Iglesias Juan, Rabano Alberto, Strange Bryan
Laboratory for Clinical Neuroscience, Center for Biomedical Technology, Universidad Politécnica de Madrid, IdISSC, Madrid, Spain.
Alzheimer's Disease Research Unit, CIEN Foundation, Queen Sofia Foundation Alzheimer Center, Madrid, Spain.
bioRxiv. 2023 Mar 10:2023.03.08.531683. doi: 10.1101/2023.03.08.531683.
Hippocampal sclerosis of aging (HS) is an important component of combined dementia neuropathology. However, the temporal evolution of its histologically-defined features is unknown. We investigated pre-mortem longitudinal hippocampal atrophy associated with HS, as well as with other dementia-associated pathologies.
We analyzed hippocampal volumes from MRI segmentations in 64 dementia patients with longitudinal MRI follow-up and post-mortem neuropathological evaluation, including HS assessment in the hippocampal head and body.
Significant HS-associated hippocampal volume changes were observed thoughout the evaluated timespan, up to 11.75 years before death. These changes were independent of age and Alzheimer’s Disease (AD) burden, and specifically driven by CA1 and subiculum. AD burden, but not HS, significantly associated with the rate of hippocampal atrophy.
HS-associated volume changes are detectable on MRI earlier than 10 years before death. These findings could contribute to the derivation of volumetric cut-offs for differentiation between HS and AD.
衰老性海马硬化（HS）是混合性痴呆神经病理学的一个重要组成部分。然而，其组织学定义特征的时间演变尚不清楚。我们研究了与HS以及其他痴呆相关病理相关的生前纵向海马萎缩情况。
我们分析了64例接受纵向MRI随访和死后神经病理学评估的痴呆患者MRI分割得到的海马体积，包括对海马头部和体部的HS评估。
在长达死亡前11.75年的整个评估时间跨度内，观察到与HS相关的显著海马体积变化。这些变化与年龄和阿尔茨海默病（AD）负担无关，且具体由CA1和海马下托驱动。AD负担而非HS与海马萎缩率显著相关。
与HS相关的体积变化在死亡前10年以上即可通过MRI检测到。这些发现可能有助于得出区分HS和AD的体积临界值。
