Department of Radiology, Faculty of Medicine, Bolu Abant İzzet Baysal University, Bolu, Turkey.
Division of Neuroradiology, Department of Radiology, Faculty of Medicine, İstanbul University-Cerrahpaşa, İstanbul, Turkey.
Turk J Med Sci. 2023 Feb;53(1):282-288. doi: 10.55730/1300-0144.5583. Epub 2023 Feb 22.
The aim of this study was to assess the effectiveness of a new quantitative index for the diagnosis of idiopathic normal pressure hydrocephalus.
This retrospective study was conducted at İstanbul University Cerrahpaşa Medical Faculty between January 2016 and November 2022. A total of 31 patients diagnosed with idiopathic normal pressure hydrocephalus were included in the study group and 48 patients were included in the control group. Measurement via the new Index was performed on a coronal section of magnetic resonance imaging at the level of the anterior commissure.
The new Index's mean diagnostic performance was 1.16 ± 0.08 in the study group, significantly lower (p < 0.0001) than the mean of 1.43 ± 0.10 in the control group. When a cutoff value of 1.23 was used for the new index, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy rates were 96.1%, 90.7%, 80.6%, 98%, and 91.3%, respectively.
The new Index described here is an effective, feasible, reproducible, highly sensitive, and specific quantitative method that can contribute to the improved diagnosis of patients with idiopathic normal pressure hydrocephalus.
本研究旨在评估一种新的定量指数在诊断特发性正常压力脑积水方面的有效性。
本回顾性研究于 2016 年 1 月至 2022 年 11 月在伊斯坦布尔大学 Cerrahpaşa 医学院进行。研究组纳入 31 例特发性正常压力脑积水患者，对照组纳入 48 例患者。通过磁共振成像在前连合水平的冠状切片上进行新指数的测量。
研究组新指数的平均诊断性能为 1.16±0.08，明显低于对照组的 1.43±0.10（p<0.0001）。当新指数的截断值为 1.23 时，其灵敏度、特异性、阳性预测值、阴性预测值和准确率分别为 96.1%、90.7%、80.6%、98%和 91.3%。
这里描述的新指数是一种有效、可行、可重复、高度敏感和特异的定量方法，有助于提高特发性正常压力脑积水患者的诊断。
