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一名成年患者因罕见的弥漫性软脑膜神经胶质神经元肿瘤出现类似中风的非典型临床表现。

Atypical clinical presentation mimicking stroke in an adult patient caused by a rare diffuse leptomeningeal glioneuronal tumour.

作者信息

Stapińska-Syniec Angelika, Gogol Anna, Acewicz Albert, Sobstyl Michał, Wierzba-Bobrowicz Teresa, Grajkowska Wiesława

机构信息

Department of Neurosurgery, Institute of Psychiatry and Neurology, Warsaw, Poland.

Department of Neurology, District Hospital in Wołomin, Wołomin, Poland.

出版信息

Pol J Pathol. 2022;73(4):371-375. doi: 10.5114/pjp.2022.125822.

Abstract

A diffuse leptomeningeal glioneuronal tumours (DLGNT) are very rare tumours of the central nervous system, typically characterized by enhancement of subarachnoid space with cystic lesions, diffuse leptomeningeal infiltration, and no primary mass. We report an atypical clinical presentation of DLGNT. A 48-year-old male was admitted to hospital with symptoms of ischaemic stroke. Magnetic resonance imaging of the head revealed contrast enhancement of the meninges and other parts of the brain. A stereotactic frame biopsy was performed on the patient, which revealed the DLGNT. Diffuse leptomeningeal glioneuronal tumours are mostly seen in individuals less than 18 years old and are characterized by slow growth and low-grade histological appearance. Diffuse leptomeningeal glioneuronal tumours can be aggressive in adults.

摘要

弥漫性软脑膜胶质神经元肿瘤(DLGNT)是中枢神经系统非常罕见的肿瘤,其典型特征是蛛网膜下腔强化伴囊性病变、软脑膜弥漫性浸润且无原发肿块。我们报告了1例DLGNT的非典型临床表现。一名48岁男性因缺血性中风症状入院。头部磁共振成像显示脑膜及脑部其他部位有强化。对该患者进行了立体定向框架活检,结果显示为DLGNT。弥漫性软脑膜胶质神经元肿瘤多见于18岁以下个体,其特点是生长缓慢且组织学表现为低级别。弥漫性软脑膜胶质神经元肿瘤在成人中可能具有侵袭性。

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