Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan.
Division of Otorhinolaryngology and Head & Neck Surgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Science, University of Fukui, Fukui, Japan.
Expert Rev Clin Immunol. 2023 Jul-Dec;19(8):857-866. doi: 10.1080/1744666X.2023.2192928. Epub 2023 Mar 30.
Chronic rhinosinusitis (CRS) comprises several heterogenous groups, now classified based on endotype more often than on phenotype. A number of studies aimed at finding a useful biomarker for type 2 CRS suggest that periostin is a promising surrogate.
A comprehensive overview of the clinical significance of tissue periostin expression and serum periostin in CRS patients is provided. The effects of comorbid asthma on serum periostin and samples other than serum in which periostin can be detected in CRS patients are also discussed. Moreover, the functional roles of periostin in CRS pathogenesis are summarized.
The position of periostin as a signature biomarker of type 2 CRS has been well established, enabling us to classify CRS patients by endotyping. Serum periostin is useful not only for endotyping CRS patients, but also for estimating disease severity, comorbidity, prognosis, and response to treatment, and in particular, predicting recurrence after surgery. However, it remains to be addressed how we apply serum periostin to using biologics for CRS patients. Further studies aimed at showing periostin to be a therapeutic target for CRS are awaited.
慢性鼻-鼻窦炎（CRS）包含多个异质群体，目前更多地基于表型而不是表型进行分类。许多旨在寻找 2 型 CRS 有用生物标志物的研究表明，骨膜蛋白是一种很有前途的替代物。
本文全面概述了组织骨膜蛋白表达和 CRS 患者血清骨膜蛋白的临床意义。还讨论了合并哮喘对血清骨膜蛋白的影响，以及除血清之外还可以在 CRS 患者中检测到骨膜蛋白的其他样本。此外，还总结了骨膜蛋白在 CRS 发病机制中的功能作用。
骨膜蛋白作为 2 型 CRS 标志性生物标志物的地位已经得到充分确立，使我们能够通过表型分类来对 CRS 患者进行分类。血清骨膜蛋白不仅可用于对 CRS 患者进行表型分类，还可用于估计疾病严重程度、合并症、预后以及对治疗的反应，特别是预测手术后的复发。然而，如何将血清骨膜蛋白应用于 CRS 患者的生物制剂治疗仍有待解决。我们期待着进一步的研究表明骨膜蛋白是 CRS 的治疗靶点。
